Publications by authors named "Narin Thippornchai"

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), led to a global pandemic from 2020. In Thailand, five waves of outbreaks were recorded, with the fourth and fifth waves driven by the Delta and Omicron variants, resulting in over 20,000 new confirmed cases daily at their peaks.

Methods: This cross-sectional study investigated the associations between clinical symptoms, vaccination status, antibody responses, and post-COVID-19 sequelae in COVID-19 patients.

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The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered global difficulties for both individuals and economies, with new variants continuing to emerge. The Delta variant of SARS-CoV-2 remains most prevalent worldwide, and it affects the efficacy of coronavirus disease 2019 (COVID-19) vaccination. Expedited testing to detect the Delta variant of SARS-CoV-2 and monitor viral transmission is necessary.

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Article Synopsis
  • Researchers investigated the antiviral properties of herbal extracts from Thai medicinal plants against SARS-CoV-2, the virus that causes COVID-19, noting the lack of specific antiviral treatments available.
  • The study screened 22 different plant extracts for their effectiveness against both porcine epidemic diarrhea virus (PEDV) and SARS-CoV-2, ultimately finding that the water fraction of mulberry leaf showed the highest antiviral potency with minimal toxicity.
  • Molecular docking analyses were performed to identify lead compounds from the effective extracts, focusing on their ability to inhibit SARS-CoV-2's main protease, which is critical for the virus's lifecycle.
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Dengue infection has been a public health problem worldwide, especially in tropical areas. A lack of sensitive diagnostic methods in the early phase of the illness is one of the challenging problems in clinical practices. We, herein, analyzed 86 sera of acute febrile patients, from both dengue and non-dengue febrile illness, to study the diagnostic performance of dengue diagnostics.

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Introduction: Co-infection of influenza A and B has been reported, especially in outbreak situations, but epidemiological and clinical information is limited. We aimed to investigate an outbreak of influenza among health care workers in which the index case suffered from influenza A and B co-infection.

Methodology: We investigated the outbreak setting through the utilization of structural questionnaires, molecular methods, and serological tests.

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Serology remains a useful indirect method of diagnosing tropical diseases, especially in dengue infection. However, the current literature regarding cross-reactivity between SARS-CoV-2 and dengue serology is limited and revealed conflicting results. As a means to uncover relevant serological insight involving antibody classes against SARS-CoV-2 and cross-reactivity, anti-SARS-CoV-2 IgA, IgM, and IgG ELISA, based on spike and nucleocapsid proteins, were selected for a fever-presenting tropical disease patient investigation.

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Background: Hepatitis E virus (HEV) is an important public health threat resulting in more than 3 million symptomatic cases and 70,000 deaths annually. HEV is classified into at least eight genotypes, and five are associated with human infection. Genotypes 1 and 2 primarily affect humans, whereas genotypes 3 and 4 circulate in both humans and swine and are considered zoonotic viruses.

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Background: The pteropine orthoreovirus (PRV) was isolated from monkey (Macaca fascicularis) faecal samples collected from human-inhabited areas in Lopburi Province, Thailand. These samples were initially obtained to survey for the presence of hepatitis E virus (HEV).

Results: Two virus isolates were retrieved by virus culture of 55 monkey faecal samples.

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Article Synopsis
  • Bovine enteroviruses (BEV) are viruses primarily found in cattle feces but also detected in other animals like goats and deer; they may be linked to disease in animals.
  • A study conducted in Thailand analyzed fecal samples from various domestic and wild animals, extracting viral RNA and examining genetic differences through advanced sequencing techniques.
  • Results showed the presence of different BEV variants in cattle and highlighted that viruses from gaurs and goats were more specific to their host species, marking the first report of BEV genetic diversity in Thailand.
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  • Severe flooding in Thailand in 2011 led to outbreaks of various infectious diseases, particularly enteric viruses.
  • Researchers collected 100 water samples from flood-affected areas to test for five human enteric viruses: enterovirus, rotavirus, norovirus, hepatitis A virus, and hepatitis E virus.
  • Norovirus was the most frequently found virus (14%), while rotavirus and hepatitis A virus were present in 9% and 7% of samples; this is the first study to identify these enteric viruses in flood water in Thailand.
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