Publications by authors named "Narimene Fradj"
, a fungal pathogen of primary timber species of North American forests, causes white root rot disease that ultimately kills the trees. A more detailed understanding of the molecular mechanisms underlying this illness will support future developments on disease resistance and management, as well as in the decomposition of cellulosic material for further use. In this study, RNA-Seq technology was used to compare the transcriptome profiles of fungal culture grown in yeast malt broth medium supplemented or not with betulin, a natural compound of the terpenoid group found in abundance in white birch bark.
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- Chaga is a medicinal fungus used in traditional Native American and North Eurasian medicine, known for its bioactive molecules that combat tumor cells, but the process of terpenoid biosynthesis is not fully understood.
- Researchers optimized growth conditions for Chaga and found that a liquid culture pH of 6.2 at 28 °C yielded the best results when using different betulin sources.
- The study used advanced sequencing technology to analyze the transcriptome, generating over 219 million reads and identifying over 20,000 transcripts, providing insights into the genetic mechanisms regulating terpenoid production and potential applications for biotechnological development.