Publications by authors named "Naresh Parajuli"

Background: The purpose of this study was to investigate the association of subclinical hypothyroidism with High sensitive C-reactive protein and lipid profile which can predispose to development of Cardiovascular disease.

Methods: This hospital-based comparative cross-sectional study was conducted for a period of six months. A total of 71 patients with subclinical hypothyroidism and 37 healthy control subjects were enrolled for the study.

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Obeticholic acid (OCA) has emerged as a promising drug in the management of nonalcoholic fatty liver disease (NAFLD). This meta-analysis aimed to analyse the therapeutic effect of OCA on NAFLD. Randomized controlled trials (RCTs) involving patients with NAFLD receiving OCA in the intervention arm and placebo in the control arm were searched throughout the electronic databases.

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Global warming and endocrine disorders are intertwined issues posing significant challenges. Greenhouse gases emanating from human activities drive global warming, leading to temperature rise and altered weather patterns. South Asia has experienced a noticeable temperature surge over the past century.

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Background: A significant number of patients face the issue of weight gain (WG) or inadequate weight loss (IWL) post-bariatric surgery for obesity. Several studies have been published evaluating the role of glucagon-like peptide-1 receptor agonists (GLP1RA) for weight loss post-bariatric surgery. However, no systematic review and meta-analysis (SRM) till date has evaluated the efficacy, safety and tolerability of GLP1RA in this clinical scenario.

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Vitamin D deficiency is a global public health concern that provokes bone demineralization and weakening. In response to the decreased vitamin D level, calcium stores wear out. The homeostatic effect of compensatory hyperparathyroidism in vitamin D deficiency incites variable discrepancies in different populations.

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Background: Thyroid dysfunction is the leading endocrine disorder worldwide. Iodine deficiency disorders, which were once the major etiology of thyroid dysfunctions, now have been succeeded by autoimmune thyroid diseases with the rise in aberrant salt ionization protocols. This study endeavors to access the level of thyroid autoantibodies viz.

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Unlabelled: Osmotic demyelination syndrome (ODS) is a neurological disorder usually after rapid correction of hyponatremia. Only few cases of ODS with hypernatremia and diabetes insipidus (DI) in postpartum state is reported. Postpartum hypernatremia is described as severe hypernatremia in postpartum period and presents as an encephalopathy with rhabdomyolysis with diffuse white matter hyperintensities suggestive of osmotic demyelination.

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Introduction And Importance: Adrenal adenomas are benign neoplasms of the adrenal cortex which can be functional or non-functional. The functional tumors manifest as Cushing syndrome. Rarely, they are associated with high levels of metanephrine due to pheochromocytoma.

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Objectives: This study intends to determine the association of parathormone with vitamin D and other biochemical parameters (calcium and phosphate) and evaluate the relationship between low vitamin D and parathormone levels.

Methods: A hospital-based cross-sectional study was conducted among 310 study participants over the period of 1 year. Patients who underwent laboratory investigations for vitamin D, parathormone, calcium, and phosphate in the Clinical Biochemistry Laboratory at the Institute of Medicine, Tribhuvan University Teaching Hospital were included.

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Unlabelled: Pituitary macroadenoma most commonly presents with visual disturbances, headache, and other symptoms secondary to adeno hypophyseal hormonal deficiencies and usually alleviates after tumor resection. Pituitary adenomas may be the cause of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) causing hyponatremia, although so far, there have only been a few documented cases. Here, we present a case of pituitary macroadenoma with SIADH and hyponatremia.

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Stiff Person Syndrome (SPS), a progressive Central Nervous System disorder is accompanied by progressive muscle rigidity, hyperreflexia, and spasms mainly in truncal and proximal leg muscles mainly associated with autoimmune disorders. Here, we report a rare case of SPS in a middle-aged Nepalese man with uncontrolled diabetes mellitus and ketonuria.

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Article Synopsis
  • A reported case involved a patient with diabetes who presented with seizures and altered awareness, initially thought to be due to high blood sugar, but scans showed brain damage typical of central pontine myelinolysis.
  • Research revealed that this syndrome can also be triggered by other factors, including autoimmune liver disease, Sjogren's syndrome, and non-Hodgkin's lymphoma, besides diabetes.
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Article Synopsis
  • Thyrotoxic periodic paralysis (TPP) is a rare condition characterized by recurring muscle weakness due to low potassium levels, often linked to thyrotoxicosis, particularly from Graves' disease, and can lead to effective treatment if recognized early.
  • A case involving a 25-year-old male experiencing recurrent limb weakness was diagnosed with thyrotoxicosis after treatment with potassium and imaging studies, highlighting the condition's potential misdiagnosis.
  • Effective management involves treating the underlying thyroid disorder and administering potassium during attacks, but caution is needed to avoid complications like hyperkalemia.
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Background: Despite criticism of the clinical performance of international medical graduates (IMGs), little is known about the views of patients within a general practice setting.

Methods: A survey was conducted to measure the responses of 1127 patients of 10 GPs, five IMGs and five Australian graduates. The General Practice Assessment Questionnaire was used to assess the attitudes of patients towards attributes of the consultation and how the patient felt in terms of understanding and coping with their problem or illness.

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