Plasma homocysteine in early and late pregnancies complicated with preeclampsia and isolated intrauterine growth restriction.

Background: Elevated circulating homocysteine is an independent risk factor for cardiovascular disease. Increased homocysteine plasma levels have been reported to occur in approximately 20-30% of women with preeclampsia and it has been suggested that they may predict the subsequent development of preeclampsia.

Methods: In a cohort of 1874 pregnant women followed longitudinally, who participated in the Down screening program, 27 developed preeclampsia and 36 intrauterine growth restriction (IUGR).

Pregnancy in essential thrombocythemia during aspirin treatment.

Introduction: Essential thrombocythemia is a rare disease of unknown origin characterized by abnormal increase in the platelet count.

Case Report: We report a case diagnosed in a woman who had had an early miscarriage in her first pregnancy, a voluntary abortion because a fetal chromosomal aberration in the second pregnancy and at last a third normal pregnancy. Treatment with low-dose aspirin (100 mg/day) and the use of low molecular weight heparin in the last three weeks of gestation appears to improve the obstetric outcome.