An improved ion chromatographic method for fast and sensitive determination of N-methylpyrrolidine in cefepime hydrochloride.

An alternative ion chromatographic method to the existing USP method for the determination of N-methylpyrrolidine (NMP) in cefepime hydrochloride is developed. The cefepime in solution behaves as a strong cation and gets retained in the analytical column, leading to reduction in column capacity and irreproducible retention time. The retained drug has to be removed with a special rinsing solution, followed by re-equilibration with the mobile phase.

Ion chromatographic determination of residual phase transfer catalyst in active pharmaceutical ingredient.

A new ion chromatography method with non-suppressed conductivity detection has been developed for the quantification of residual phase transfer catalyst-tetrabutylammonium bromide (TBAB) in an active pharmaceutical drug, Levetiracetam. Separation conditions are optimized to get a clear separation of TBAB from drug impurities using a Metrosep Cation C2-150 column. Conditions are also optimized to separate tetramethylammonium bromide, tetraethylammonium bromide, and tetrapropylammonium bromide, which are also used as phase transfer catalysts in several syntheses.

Matrix elimination ion chromatography method for trace level azide determination in irbesartan drug.

Ultra-trace analysis of azide in complicated Irbesartan sample matrix is achieved by the in-line sample preparation technique. Sodium azide is the precursor of Irbesartan, which is used as an anti-hypertensive drug. Due to the toxic nature of sodium azide, reliable determination of azide in Irbesartan is necessary.