Estimation of Plasma Concentration of L-Carnosine and its Correlation with Core Symptoms of Autism Spectrum Disorder Children: A Pilot Clinical Trial.

Background: Literature indicates that L-carnosine may be deficient in autism spectrum disorder (ASD) children. The aim of the present study was to estimate the level of L-carnosine in plasma and correlate it with the Autism Treatment Evaluation Checklist (ATEC) and Childhood Autism Rating Scale 2nd Edition, Standard Version (CARS2-ST) scores. To measure L-carnosine level, a bio-analytical method was developed using reverse phase high- liquid chromatography and validated as per International Conference on Harmonization guidelines.

Diagnostic Accuracy of Bayley III Screening Tool to Detect Developmental Delay in Moderate to High-Risk Indian Preterm Children.

The present study aimed to evaluate the ability of the Bayley III screening tool to detect developmental delay in moderate to high-risk preterm children in India. In this cross-sectional study, 94 preterm babies were enrolled. The Bayley III screener (index test) and the gold-standard, Developmental assessment scale for Indian Infants (DASII) test were administered to all the enrolled children.

Quantitative assessment of cognitive profile and brain asymmetry in the characterization of autism spectrum in children: A task-based EEG study.

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by learning, attention, social, communication, and behavioral impairments. Each person with Autism has a different severity and level of brain functioning, ranging from high functioning (HF) to low functioning (LF), depending on their intellectual/developmental abilities. Identifying the level of functionality remains crucial in understanding the cognitive abilities of Autistic children.

Effectiveness of Bedside Clinical Screening Tools in Predicting Short-Term Neurodevelopmental Delay Among Very-Low-Birth-Weight Pre-terms: A Prospective Observational Study.

Background: Pre-term births are associated with increased risk of various morbidities, especially neurological. Early detection and early intervention to prevent these morbidities will have immediate and long-term benefits to the individuals and society at large. However, the screening and assessment tools, including both clinical and radiological, are not uniformly available in resource-poor settings.

Association of digital media exposure and addiction with child development and behavior: A cross-sectional study.

Background: Media exposure which was traditionally restricted only to television has now broadened to include various handheld devices and constant internet access. Although high quality educational and interactive screen time is beneficial, excessive addiction and early introduction of such media use has various deleterious consequences.

Aim: To estimate the exposure of media among Indian children and its influence on early child development and behaviour.

Seeing the National Education Policy 2020 through the lens of early child development.

Globally there is a revolution in science with digitalisation and artificial intelligence. A country's investment in education is crucial to manage the knowledge economy. Early childhood education is the foundation for future academic success and life skills.

Atypical presentation of rapid-onset dystonia-parkinsonism in a toddler with a novel mutation in the ATP1A3 gene.

ATP1A3 gene mutations can result in a spectrum of diseases with diverse neurological manifestations. One such disorder linked to this mutation is rapid-onset dystonia-parkinsonism (RDP), which manifests as dystonia with features of parkinsonism, such as tremors, rigidity, muscle spasms, and bulbar symptoms. Affected patients are typically adolescents or young adults, with symptoms occurring in a rostrocaudal pattern.

Effect of L-Carnosine in children with autism spectrum disorders: a systematic review and meta-analysis of randomised controlled trials.

Autism spectrum disorders (ASD) are an emerging health problem worldwide. So far, no definite cure for ASD exists. L-Carnosine is an amino acid containing β-alanine and L-histidine which has been proposed to have neuroprotective, antioxidant and anti-convulsive properties that may benefit affected children with this disorder.

Effect of L-Carnosine as adjunctive therapy in the management of children with autism spectrum disorder: a randomized controlled study.

L-Carnosine is an amino acid that acts as an anti-oxidant, anti-toxic and neuroprotective agent. There is a paucity of data about the effectiveness of L-Carnosine in the management of autism spectrum disorder (ASD) in children. This study aimed at investigating the effectiveness of L-Carnosine as adjunctive therapy in the management of ASD.

Pyridoxine and Magnesium Administration-Induced Hyperactivity in Two Children With Autism Spectrum Disorder: Case Reports From a Clinical Trial.

Purpose: Pyridoxine hydrochloride and magnesium sulfate (pyridoxine-Mg) have been used for the management of autism spectrum disorder (ASD). We present a case report of 2 children with ASD who were administered pyridoxine-Mg for 2 months.

Methods: The Childhood Autism Rating Scale, Second Edition, was used to confirm the adverse reaction.

The Spectrum of Sleep Disorders Among Children: A Cross-sectional Study at a South Indian Tertiary Care Hospital.

Introduction Sleep problems during infancy and early childhood are fairly common and rarely recognized in pediatric practice. These are mostly related to the initiation and maintenance of night-time sleep. Understanding sleep patterns and disorders associated with sleep is challenging, especially in the pediatric age group.

Specific Learning Disability Unmasked by Psychophysiological Insomnia.

Sleep is essential for good cognition and academic performance. Children with deficits in learning and cognition thus have various sleep disturbances. Learning disabilities in dyslexia are exaggerated with associated sleep problems which also impact the daily routine.

Parenting Styles of Parents Who Had Children With and Without High Risk at Birth: A Cross-sectional Comparative Study.

Introduction Parenting style plays a major role in child development by influencing cognitive, social-emotional development, academic performance, and behavioral problems. These characteristics are fairly stable right into adulthood. The influence of risk factors in children on the parenting style of mothers and fathers has not been studied in developing countries.

Coronavirus disease 2019 and the inevitable increase in screen time among Indian children: Is going digital the way forward?

The world is facing an unprecedented crisis due to the Coronavirus disease catastrophe. The pandemic has been ravaging for the past six months claiming human lives, causing financial loss, and job insecurity. Children are susceptible to the psychosocial aspects of this pandemic.