Publications by authors named "Narang Hong"
Detecting T-cell receptor clonality in patients with severe atopic dermatitis refractory to dupilumab.
J Eur Acad Dermatol Venereol
October 2024
Background: Trials and real-life studies demonstrated clinically meaningful improvements of disease activity in the majority of patients with moderate to severe atopic dermatitis (AD) treated with the anti-IL-4RA-antibody dupilumab. However, misdiagnosis or confounding skin diseases in particular cutaneous T-cell lymphoma (CTCL) may lead to inadequate response.
Objective: To investigate the clinical and pathological features of patients with AD who showed insufficient response to dupilumab.
Article Synopsis
- * A case study of a 46-year-old male with AIDS revealed an erythematous patch on his forearm, which was ultimately diagnosed as an early patch stage of KS through histological analysis showing abnormal blood vessel growth and positive HHV-8 staining.
- * Early-stage KS can often be misdiagnosed due to its similar appearance to other conditions, highlighting the importance of accurate pathological assessment in HIV-positive patients with vascular lesions.
Tuberculous lymphadenitis is among the most frequent presentations of extrapulmonary tuberculosis; the most common presentation is isolated chronic non-tender lymphadenopathy in young adults without systemic symptoms. Dupilumab is a fully human monoclonal antibody directed against interleukin-4 receptor-α that blocks the synergistic effects of interleukin-4 and interleukin-13 on allergic inflammation. Its well-known adverse events are allergic conjunctivitis, injection site reaction, and dupilumab facial redness.
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