Levels of arsenic in liver cirrhosis.

The present studies were conducted to determine the arsenic levels in liver specimens obtained at autopsy from human subjects suffering from liver cirrhosis. Arsenic content was determined using the neutron activation analysis technique. Increased levels of arsenic were found in cirrhotic liver samples including alcoholic cirrhosis.

Impairment of hepatic drug metabolism in patients with acute viral hepatitis.

Hepatic drug metabolism in patients with acute viral hepatitis was investigated under different conditions: pregnancy, postpartum, non-pregnancy, and among males. Liver function tests were altered in all of these conditions. The relationship between in vivo and in vitro drug metabolism was studied in twenty-two patients using diagnostic liver needle biopsies by comparing the drug metabolising enzymes (aminopyrine-N-demethylase and bilirubin-UDP-glucuronyl transferase) in these biopsies with the elimination kinetics of antipyrine.

Antipyrine clearance, aminopyrine N-demethylase, and bilirubin UDP-glucuronyl transferase activity in patients with amoebic liver abscess.

Three indices of drug metabolism, antipyrine clearance in vivo, and aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase activity in liver biopsies, were studied in fifteen patients with amoebic liver abscess (with and without jaundice). The mean (+/- S.E.

In vivo and in vitro drug metabolism in patients with leprosy.

Plasma antipyrine and chloramphenicol clearance was studied in 23 patients of leprosy and 12 control subjects. Drug metabolising enzymes (aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase) were estimated in liver biopsy samples of twelve patients and ten controls. A significant decrease in drug clearance and drug metabolising enzymes was observed.

5'Chloropuromycin. Inhibition of protein synthesis and antitrypanosomal activity.

A facile, two-step conversion of puromycin aminonucleoside (PAN) into 5'-deoxy-PAN (5) via 5'-chloro-5'-deoxy-PAN (1) was accomplished. Replacement of the 5'-OH group of PAN with H or Cl resulted in the elimination of kidney toxicity associated with the administration of PAN. The corresponding puromycin derivatives, 5'-chloro-5'-deoxypuromycin (4) and 5'-deoxypuromycin (6), derived from 1 and 5, respectively, were compared in a ribosomal peptidyltransferase assay.

The steatocrit: a simple method for estimating stool fat content in newborn infants.

A simple micromethod is described for estimating the stool fat content of newborn babies. It is quick and reliable, requires only a small amount of stool, and can be used as a screening test for newborn babies suspected of fat malabsorption.

Pharmacokinetic study of chloramphenicol in patients with liver disease.

The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t 1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under the time - concentrations curve (AUC) showed an increase. The t 1/2 of chloramphenicol showed a significant correlation with serum albumin and prothrombin time index.

Delayed Cutaneous Hypersensitivity Responses in Patients with Warts.

Twenty five patients of viral warts were tested with various antigens of secondary,(recall antigens), primary delayed (DNCB) and inflammatory (croton oil) type. Significantly depresed responses were elicited with various antigens in patients with warts as compared to controls.

Acro-osteolysis (report of two cases and brief review of literature.

Two siblings suffering from acro-osteolysis, a rare disorder, are discussed. Although three distinct types of acro-osteolysis, namely familial, idiopathic, and due to vinyl-chloride, are clearly defined, these patients did not fit into any category. They had intact nails, preserved tactile and sensory system, plantar ulceration and so sensory deficit.