Postpartum HELLP syndrome complicated with large subcapsular liver hematoma.

Subcapsular hematoma of the liver is a potentially fatal complication of pregnancy-related hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. In turn, HELLP syndrome is one of the most critical complications of preeclampsia. We present a case of a 31-year-old woman who developed a subcapsular liver hematoma in the postpartum period secondary to HELLP syndrome.

Exergy, advance exergy, and exergo-environmental based assessment of alkanol amine- and piperazine-based solvents for natural gas purification.

Purification of Natural gas is vital for utilizing it as a source of energy harvesting for the world. Amine-based chemical absorption technique is the most utilized in the gas field for the purification of gas that ensures the purity of the sweet gas stream with the elimination of carbon dioxide. However, it is considered an energy-intensive process to deal with considerable energy loss and environmental damage to the ecosystem.

Novel NARC-G1 garlic: comparative allicin quantification with morpho-biochemical & genetic profiling.

Garlic (Allium sativum) is an important cash food crop, and the biotechnology industry has considerable interest in the plant because of its medicinal importance. These medicinal properties are attributed to organosulphur compounds as the accumulation of these compounds varies according to genotype, locality, light quality, and cultivation practices. In this study, we compared a newly developed garlic variety NARC-G1 by National Agricultural Research Centre (NARC), Islamabad, Pakistan with three different garlic cultivars and highlighted the distinctive attributes like phenotypic characteristics, the content of allicin, elemental profile, and gene polymorphism.

Benign and Malignant Skin Lesions: Dielectric Characterization, Modelling and Analysis in Frequency Band 1 to 14 GHz.

Objective: This paper aims to characterize Non-Melanoma malignancies and their corresponding benign conditions in ex-vivo/in-vivo tissue environments to study the feasibility of microwave techniques for skin cancer detection.

Methods: The dielectric dataset is developed across the frequency band 1 to 14 GHz using Keysight slim-form and RG405 probe characterization systems. The acquired reflection data captured by the systems is converted to dielectric values using the Open-Water-Short and Open-Water-Liquid calibration methods, respectively.

Evaluation of operational and financial viability models of combined landfill site for intermediate cities in Pakistan.

This study aims to evaluate municipal landfill sites' operational and financial viability, waste amount and characterization, primary and secondary collection systems, revenue generation from MSW, vehicle routing, and age of landfill sites located in Akhtarabad, Sahiwal Division. Three operational and financial models were developed to calculate cost/ton value based on obtained data. The obtained results indicate that the cost/ton values for models are the following: 20.

Glutamine metabolism modulates chondrocyte inflammatory response.

Osteoarthritis is the most common joint disease in the world with significant societal consequences but lacks effective disease-modifying interventions. The pathophysiology consists of a prominent inflammatory component that can be targeted to prevent cartilage degradation and structural defects. Intracellular metabolism has emerged as a culprit of the inflammatory response in chondrocytes, with both processes co-regulating each other.

Successes and challenges of latent TB screening and treatment in a high-prevalence US region.

South Texas has higher TB disease incidence than much of the United States. We evaluated a multi-site South Texas interferon-gamma release assay (IGRA)-based testing and latent TB infection (LTBI) treatment program targeting high-risk populations. Number of IGRA tests, test results, LTBI confirmation, and treatment outcomes were collected over 2.

Evolutionary Dynamics of Foot and Mouth Disease Virus Serotype A and Its Endemic Sub-Lineage A/ASIA/Iran-05/SIS-13 in Pakistan.

Foot and mouth disease (FMD) causes severe economic losses to the livestock industry of endemic countries, including Pakistan. Pakistan is part of the endemic pool 3 for foot and mouth disease viruses (FMDV), characterized by co-circulating O, A, and Asia 1 serotypes, as designated by the world reference laboratory for FMD (WRL-FMD). FMDV serotype A lineage ASIA/Iran-05 is widespread in buffalos and cattle populations and was first reported in Pakistan in 2006.

Early Experience of Undertaking Robotic Assisted Total Mesorectal Excision in Rectal Resections, Avoiding a Diverting Stoma: Key eHancement of the Anastomosis for No Stoma Technique - A Case Series.

Anastomotic leak is a feared complication in rectal cancer surgery, and a proximal diverting stoma to protect the rectal anastomosis is used to minimize its impact. We evaluated a novel technique that uses the da Vinci® robotic platform (Intuitive Surgical) to reinforce the colorectal anastomosis and rectal staple line with sutures, and rectal resection and assessment of the anastomotic perfusion, using our Portsmouth protocol. During robotic rectal cancer surgery, we used indocyanine green to determine the level of transection and check the vascularity of the circular anastomosis.

Sensitive and highly selective colorimetric biosensing of vitamin-C and vitamin-B1 by flavoring agent-based silver nanoparticles.

A sensitive scheme was established for the detection of vitamin C (Ascorbic acid) and vitamin B1 (Thiamin HCl) using Maltol capped AgNPs (McAgNPs) as colorimetric sensor. The designed scheme showed an instant alteration in color from yellow to orange and green for vitamin-C and vitamin B1 sequentially. The probe was sensitive in a concentration range of (0-1 µM) with limit of detection 0.

Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks.

Gene regulatory networks ensure that important genes are expressed at precise levels. When gene expression is sufficiently perturbed, it can lead to disease. To understand how gene expression disruptions percolate through a network, we must first map connections between regulatory genes and their downstream targets.

Burden of Congenital and Hereditary Anomalies in Hazara Population of Khyber Pakhtunkhwa, Pakistan.

Background And Objectives: In Pakistan, there is high incidence of congenital and hereditary anomalies (CA) which are a leading cause of infant mortality and morbidity. In order to elucidate the burden and biodemographic correlates of CA, this study was aimed to report the prevalence-pattern and phenotypic attributes of CA in the Hazara population of Khyber Pakhtunkhwa, Pakistan.

Methods: In a retrospective cross-sectional study, subjects/families with CA were recruited from district hospitals and community centers.

New cardiovascular events in the convalescent period among survivors of SARS-CoV-2 infection.

Background: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have an increased risk of acute cardiovascular events in the convalescent period.

Aims: To determine whether patients with SARS-CoV-2 infection have an increased risk of cardiovascular events during the convalescent period.

Methods: We analyzed 10,691 hospitalized adult pneumonia patients with SARS-CoV-2 infection and contemporary matched controls of pneumonia patients without SARS-CoV-2 infection.

Recent progress in microalgae-derived biochar for the treatment of textile industry wastewater.

Textile industry utilize a massive amount of dyes for coloring. The dye-containing effluent is released into wastewater along with heavy metals that are part of dye structure. The treatment of textile industry wastewater using conventional techniques (coagulation, membrane technique, electrolysis ion exchange, etc.

Corrigendum: Role of Promising Secondary Metabolites to Confer Resistance Against Environmental Stresses in Crop Plants: Current Scenario and Future Perspectives.

[This corrects the article DOI: 10.3389/fpls.2022.

Transdiagnostic symptom dynamics during psychotherapy.

Psychotherapy is an effective treatment for many common mental health problems, but the mechanisms of action and processes of change are unclear, perhaps driven by the focus on a single diagnosis which does not reflect the heterogeneous symptom experiences of many patients. The objective of this study was to better understand therapeutic change, by illustrating how symptoms evolve and interact during psychotherapy. Data from 113,608 patients from psychological therapy services who completed depression and anxiety symptom measures across three to six therapy sessions were analysed.

Long-Term Isothermal Phase Transformation in Lead Zirconate.

Lead zirconate PbZrO has been the subject of research interest for several dozen years. Recently, even its antiferroelectric properties have started to be questioned, and many researchers still deal with the so-called intermediate phase below Curie temperature (T), whose existence is not fully understood. It turns out that PbZrO doped with Nb exhibits below T phases with complex domain structures.

Impact of an electronic medical record-based automated screening program for critical congenital heart disease: Emirates Health Services, United Arab Emirates.

Background: Almost eight children per 1000 live births are expected to have a congenital heart defect globally. The seven most critical congenital heart conditions that cause severe compromise on the patient's quality and duration of life are collectively referred to as the Critical Congenital Heart Diseases (CCHD). CCHD is a critical condition that requires prompt detection and intervention as a life-saving measure.

Levels of perceived stress according to professional standings among dental surgeons of Karachi: a descriptive study.

Background: Globally, occupational stress is a common finding among dentists. The present study aimed to assess prevalence of perceived stress among practicing dentists of Karachi, Pakistan, and assess the perceived stress levels according to the professional standing among dental surgeons.

Methods: A cross-sectional survey was conducted using a convenience sampling technique in which 200 dentists from Karachi were recruited.

Assessment of Pathological Complete Response in Patients with Breast Cancer Receiving Neoadjuvant Systemic Therapy.

Objective: To quantify the rate of pathological complete response (PCR) in a tertiary care hospital in Pakistan, and to explore the association of pathological complete response with tumour histology, tumour grade, and histological subtype based on receptors.

Study Design: Descriptive study.

Place And Duration Of Study: Combined Military Hospital, Rawalpindi, Pakistan from January 2016 to December 2018.

Experimental Study of Potential CD8 Trivalent Synthetic Peptides for Liver Cancer Vaccine Development Using Sprague Dawley Rat Models.

Background: Liver cancer (LC) is the most devastating disease affecting a large set of populations in the world. The mortality due to LC is escalating, indicating the lack of effective therapeutic options. Immunotherapeutic agents may play an important role against cancer cells.

Isolation and characterization of novel antihypertensive bioactive peptides from brassica napus and angiotensin-converting enzyme (ace) inhibition potential.

Present study aimed to explore the antihypertensive potential of bioactive peptides isolated from Brassica napus protein as inhibitor of angiotensin converting enzyme. Protein was extracted and assessed for antihypertensive potential. The extracted protein showed 72% antihypertensive activity/potential with IC value of 24±5.

Comparison of the Efficacy of Continuous Femoral Nerve Block With Epidural Analgesia for Postoperative Pain Relief After Unilateral Total Knee Replacement.

Introduction With recent developments in postoperative pain management after total knee replacement (TKR), the continuous femoral nerve block is becoming a common practice. The purpose of this study was to compare a femoral nerve block with time-tested epidural analgesia in a tertiary care setup in a developing country. Methodology A randomized control trial took place at Shifa International Hospital (SIH), Islamabad, Pakistan.