Publications by authors named "Nappa P"
Real-life effectiveness and safety of baricitinib in patients with severe alopecia areata: A 24-week Italian study.
J Eur Acad Dermatol Venereol
September 2024
Background: Alopecia areata is an autoimmune condition characterized by rapid hair loss in the scalp, eyebrows and eyelashes, for which treatments are limited. Baricitinib, an oral inhibitor of Janus kinases 1 and 2, has been recently approved to treat alopecia areata.
Materials And Methods: We conducted a retrospective study involving 23 medical centres across Italy, enrolling patients affected by severe alopecia areata (SALT >50), for more than 6 months.
Article Synopsis
- * Researchers found that 8 patients had autosomal recessive ichthyosis, while others had X-linked ichthyosis, with a total of 24 disease-causing alleles identified, including 8 novel variants.
- * The findings help enhance early diagnosis and classification of ichthyosis patients, broadening the understanding of the genetic and phenotypic diversity of inherited ichthyosis disorders.
Article Synopsis
- The study investigates the dermatological manifestations of COVID-19 in children, particularly noting the prevalence of chilblain-like lesions among infected and non-infected patients, attributed to a pronounced interferon response in younger individuals.
- Conducted over six months, the research involved 137 patients aged 1 to 18 from 23 Italian dermatological units, who exhibited a variety of skin lesions primarily on the feet.
- Results showed diverse skin symptoms, with many experiencing concomitant systemic symptoms, highlighting the complex interplay of dermatological and respiratory issues related to COVID-19 in children.
Reply to 'A case of dystrophic epidermolysis bullosa pruriginosa treated with dupilumab' by Caroppo et al.
J Eur Acad Dermatol Venereol
September 2022
Article Synopsis
- Chilblain-like lesions became common during the COVID-19 pandemic, but their connection to SARS-CoV-2 infection is still unclear.
- A study at a hospital in Italy involved 17 adolescents with these lesions to examine their characteristics and possible links to the virus.
- Results indicated that while the lesions had distinct features, extensive testing showed no evidence of SARS-CoV-2 infection, suggesting that these skin manifestations are not associated with the virus.
Oral minoxidil (OM) has been reported to be effective for androgenetic alopecia (AGA). In this retrospective study, we share our experience of using OM for >24 weeks in 12 patients with female AGA (Ludwig scale I-3-III). Twelve women (aged 18-66 years; mean age 36.
View Article and Find Full Text PDFDermatomyositis (DM) is an autoimmune disease that primarily affects the skin and muscles, but may also have a systemic involvement. The frequency of scalp involvement in DM varies from 28 to 82% and is often encountered as part of a DM flare. However, it frequently presents as a treatment-resistant disease, and patients reporting no improvement with conventional therapies require further investigation.
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