Reliable detection of low visual acuity in mice with pattern visually evoked potentials.

Measuring the optokinetic response (OKR) to rotating sinusoidal gratings is becoming an increasingly common method to determine visual function thresholds in mice. This is possible also through direct electrophysiological recording of the response of the neurons in the visual cortex to the presentation of reversing patterned stimuli, i.e.

Retained Plasticity and Substantial Recovery of Rod-Mediated Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy.

In patients born blind with retinal dystrophies, understanding the critical periods of cortical plasticity is important for successful visual restoration. In this study, we sought to model childhood blindness and investigate the plasticity of visual pathways. To this end, we generated double-mutant (Pde6cGnat1) mice with absent rod and cone photoreceptor function, and we evaluated their response for restoring rod (GNAT1) function through gene therapy.

Measurement of Electroretinograms and Visually Evoked Potentials in Awake Moving Mice.

The development of new treatments for intractable retinal diseases requires reliable functional assessment tools for animal models. In vivo measurements of neural activity within visual pathways, including electroretinogram (ERG) and visually evoked potential (VEP) recordings, are commonly used for such purposes. In mice, the ERG and VEPs are usually recorded under general anesthesia, a state that may alter sensory transduction and neurotransmission, but seldom in awake freely moving mice.