Total Synthesis of Biselyngbyaside.

The first total synthesis of biselyngbyaside, an 18-membered macrolide glycoside, was achieved. The glycoside bond was introduced using the Schmidt method before construction of the 18-membered ring due to the instability of the conjugated diene and the β-hydroxy ester moiety. The macrolactone ring was constructed using the Mitsunobu reaction followed by intramolecular the Stille coupling reaction.

Total Synthesis of Biselyngbyolide B.

The first total synthesis of biselyngbyolide B, an 18-membered macrolide, was achieved. The 18-membered ring structure was constructed by esterification using the Shiina reagent and an intramolecular Stille coupling reaction.

Total synthesis of biselyngbyolide A.

Biselyngbyolide A is an 18-membered macrolide that exhibits significant biological activities such as growth-inhibitory activity and apoptosis inducing activity against cancer cells. In this study, the first total synthesis of biselyngbyolide A by using an intramolecular Stille coupling reaction as a key step is achieved.

[Causes of death in hospitalized elderly patients].

Aim: The Juntendo Tokyo Koto Geriatric Medical Center (JTKGMC) is a community hospital catering for the health care needs of senior citizens, and 37.5% (120 beds) of its beds are psychiatric beds mostly for those with cognitive impairment. The purpose of this study was to analyze cause of death in a hospital like ours with its particular case mix.

[Clinical study on lung disease caused by non-tuberculous mycobacteriosis in the elderly].

Aim: This study was done to clarify the characteristics of elderly patients with nontuberculous mycobacteriosis.

Methods: We investigated the clinical features of 10 patients at an advanced age who had been given diagnosis of nontuberculous mycobacteriosis.

Results: Mycobacterium avium intracellulare complex (MAC) were detected in all cases.