Preparation of gold nanoparticles using low-temperature heating of the dry residue of a droplet of an HAuCl solution in air.

In the present study, by heating a quartz glass substrate having the dry residue of a 10 μL droplet of a solution of HAuCl and a counter substrate facing to the dry residue from room temperature to one hundred and several tens of degrees Celsius in 20 min in air, highly dense gold nanoparticles were produced on the counter substrate. A gold nanoparticle substrate produced by this simple method was utilized as a substrate for surface-enhanced Raman scattering analysis.

Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population.

Background: Clozapine-induced agranulocytosis (CIA)/clozapine-induced granulocytopenia (CIG) (CIAG) is a life-threatening event for schizophrenic subjects treated with clozapine.

Methods: To examine the genetic factor for CIAG, a genome-wide pharmacogenomic analysis was conducted using 50 subjects with CIAG and 2905 control subjects.

Results: We identified a significant association in the human leukocyte antigen (HLA) region (rs1800625, p = 3.