Publications by authors named "Naoya Kenmotsu"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are effective for treating advanced cancers, but many patients do not respond to this form of immunotherapy, necessitating new approaches like boron neutron capture therapy (BNCT).
- The study introduces boron neutron immunotherapy (B-NIT), which combines BNCT with ICI immunotherapy, showing enhanced tumor suppression in a mouse model of advanced-stage melanoma compared to either treatment alone.
- B-NIT not only increased the infiltration of effective CD8+ T-cells in tumors but also demonstrated a strong abscopal effect, suggesting it could be a promising new treatment option for overcoming resistance in advanced-stage malignancies.
