Publications by authors named "Naoya Kemmotsu"
Objective: The extent of resection (EOR) is an important prognostic factor for both low- and high-grade gliomas. Intraoperative MRI (iMRI) has been used to increase the EOR in glioma surgery. While a recent study reported differences between iMRI and early postoperative MRI (epMRI), their specific relationship to postoperative clinical symptoms remains unclear.
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- Tectal glioma (TG) is a rare, lower grade glioma primarily found in children, but this study identified cases in older patients, with a median age of 30.5 years.
- The study reviewed six TG cases treated at an institute from 2005 to 2023, highlighting diverse diagnoses including pilocytic astrocytoma and high-grade gliomas, based on histological evaluations.
- Genetic analysis revealed distinct mutations in two cases, emphasizing the importance of thorough diagnostics, including molecular evaluation, to understand the varied characteristics of TG.
Intracranial metastases are common in nonsmall-cell lung cancer (NSCLC) patients, whose prognosis is very poor. In addition, intracranial progression is common during systemic treatments due to the inability to penetrate central nervous system (CNS) barriers, whereas the intracranial effects of cancer immunotherapies remain unclear. We analyzed clinical data to evaluate the frequency of intracranial progression in advanced NSCLC patients treated with PD-1 blockade therapies compared with those treated without PD-1 blockade therapies, and found that the frequency of intracranial progression in advanced NSCLC patients treated with PD-1 blockade therapies was significantly lower than that in patients treated with cytotoxic chemotherapies.
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- * In experiments with mouse models, the combination of H₂O₂ and RT led to a significant increase in immune cells, particularly matured dendritic cells and CD8 T cells, in the non-treated tumor sites, indicating a boost in antitumor immunity.
- * Additionally, blocking the PD-1 receptor enhanced the antitumor effect seen with the H₂O₂/RT combination, suggesting potential for this treatment strategy in cancer immunotherapy, especially for advanced cases
Purpose: Pilocytic astrocytoma (PA) is a circumscribed low-grade astrocytic glioma, generally considered to be associated with a good prognosis. However, a subset of PA patients shows unfavorable outcomes. In this study, we retrospectively reviewed PA patients and performed further molecular analysis, such as DNA methylation profiling, to identify prognostic factors.
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