Osteoarthritis (OA) is the most prevalent joint disorder associated with severe chronic pain. Although synovial inflammation is well correlated with pain severity, the molecular mechanism responsible for OA pain remains unclear. Here, we show that extracellular miR-21 released from synovial tissue mediates knee OA pain in surgical OA model rats.
View Article and Find Full Text PDFBackground: The influence of varus insertion of femoral implants in uncemented total hip replacement arthroplasty (THR) remains unclear. Thus, in this study, we retrospectively assessed the clinical impact of uncemented THR with femoral implants that were inserted in varus on the basis of radiological findings.
Materials And Methods: The study participants included 89 patients who underwent uncemented THR for 106 joints and were followed-up for >3 years.
Unlabelled: Recent reports suggest that uncemented total hip replacement arthroplasty (THR) results in favorable short- to mid-term clinical results. In the present study, we assessed the mid-term clinical results of VerSys Hip System uncemented THR at our hospital.
Materials And Methods: We studied patients who received THR using VerSys Hip System and who could be followed-up more than 3 years.
Introduction: We usually use short femoral nails for the treatment of trochanteric fracture of the femur. In this retrospective study, we investigated and compared the clinical results of the conventional intramedullary hip screw (IMHS) and the Asian IMHS, which is a redesigned version of the former.
Materials And Methods: The subjects were 42 patients; 21 treated with the Asian IMHS and 21 were treated with the conventional IMHS.