Publications by authors named "Naoya Arakawa"
Article Synopsis
- The study investigates the clinical features of patients with cryopyrin-associated periodic syndrome (CAPS) in Japan and assesses the effectiveness and safety of the IL-1 inhibitor canakinumab in treating these patients.
- Out of 101 patients analyzed, a significant majority achieved complete remission with canakinumab, but 23.7% did not respond, experiencing serious complications including deaths and organ damage.
- The research highlights the importance of early intervention and suggests that combining canakinumab with other therapies can be beneficial for those who don't adequately respond to canakinumab alone.
Oxidative stress increases the production of the predominant mucin MUC5AC in airway epithelial cells and is implicated in the pathogenesis of bronchial asthma and chronic obstructive pulmonary disease. Oxidative stress impairs mitochondria, releasing mitochondrial DNA into the cytoplasm and inducing inflammation through the intracytoplasmic DNA sensor STING (stimulator of interferon genes). However, the role of innate immunity in mucin production remains unknown.
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- A case study highlighted successful tolerance to trigger foods and symptom relief in non-EoE EGID after using dupilumab, following earlier treatments with elimination diets and other biologics.
- The study reviewed seven articles on different biologics and found dupilumab may uniquely address symptoms triggered by certain foods, suggesting further research is necessary for non-EoE EGID therapies.
The lymphocyte stimulation test (LST) facilitates the diagnosis of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs). However, LSTs require large volumes of blood and prolonged culture durations. Recently, we found that mRNA expression in peripheral blood mononuclear cells (PBMCs) of patients with non-IgE-GI-FAs increased after a 24 h stimulation with milk proteins.
View Article and Find Full Text PDFDuring late 1960s Green Revolution, researchers utilized semidwarf 1 (sd1) to improve the yield and lodging resistance in rice (Oryza sativa L.). However, sd1 has a negative effect to culm strength and biomass production.
View Article and Find Full Text PDFWe propose a stabilizing mechanism for the Bose-Einstein condensation (BEC) of interacting magnons in ferrimagnets and ferromagnets. By studying the effects of the magnon-magnon interaction on the stability of the magnon BEC in a ferrimagnet and two ferromagnets, we show that the magnon BEC remains stable even in the presence of the magnon-magnon interaction in the ferrimagnet and ferromagnet with a sublattice structure, while it becomes unstable in the ferromagnet without a sublattice structure. This indicates that the existence of a sublattice structure is the key to stabilizing the BEC of interacting magnons, and the difference between the spin alignments of a ferrimagnet and a ferromagnet is irrelevant.
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