Publications by authors named "Naoufel-Ali Zeggwagh"
Aqueous Extract Exhibits Antidiabetic and Hepatoprotective Effects in Streptozotocin-Induced Diabetic Rats.
Endocr Metab Immune Disord Drug Targets
August 2019
Article Synopsis
- The study aimed to evaluate the blood sugar-lowering effects of the aqueous extract from the aerial parts of Mentha pulegium (M. pulegium) in both normal and diabetic rats.
- The extract (20 mg/kg) significantly reduced blood glucose levels in STZ-induced diabetic rats and improved glucose tolerance in normal rats, with beneficial changes observed in liver and pancreas tissues.
- Preliminary phytochemical analysis revealed the presence of various bioactive compounds, suggesting that M. pulegium could be a potential natural treatment for managing diabetes.
Objective: As the aqueous extract of (CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice.
Materials And Methods: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity.
Background: Globally, the prevalence of diabetes mellitus is increasing at an alarming rate. This chronic pathology gravely troubled the human health and quality of life. Both insulin deficiency and insulin resistance are involved in the pathophysiology of diabetes mellitus.
View Article and Find Full Text PDFAnimal models as tools to investigate antidiabetic and anti-inflammatory plants.
Evid Based Complement Alternat Med
September 2012
Plants have been historically used for diabetes treatment and related anti-inflammatory activity throughout the world; few of them have been validated by scientific criteria. Recently, a large diversity of animal models has been developed for better understanding the pathogenesis of diabetes mellitus and its underlying inflammatory mechanism and new drugs have been introduced in the market to treat this disease. The aim of this work is to review the available animal models of diabetes and anti-inflammatory activity along with some in vitro models which have been used as tools to investigate the mechanism of action of drugs with potential antidiabetic properties and related anti-inflammatory mechanism.
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- - The study investigates the vasorelaxant effects of C. nobile aqueous extract using isolated aortic rings from Wistar rats.
- - Three different doses of the extract (5, 10, and 20 mg/ml) were tested and showed a significant shift in the dose-response curve to norepinephrine after 30 minutes (p < 0.001).
- - The findings indicate that C. nobile aqueous extract has a notable vasorelaxant effect in vitro.
Article Synopsis
- - The study investigates the blood pressure-lowering effects of Chamaemelum nobile aqueous extract (CNAE) in spontaneously hypertensive rats (SHRs).
- - A single dose of CNAE (140 mg/kg) resulted in a significant drop in systolic blood pressure after 24 hours, and continued daily doses led to sustained reductions starting from day 8 of treatment.
- - CNAE also increased urinary output and electrolyte excretion, confirming its hypotensive and diuretic properties in the test subjects.
The antihypertensive and diuretic effects of the aqueous extract of Lepidium sativum L. (LS) were studied both in normotensive (WKY) and spontaneously hypertensive rats (SHR). Daily oral administration of the aqueous LS extract (20mg/kg for 3 weeks) exhibited a significant decrease in blood pressure (p<0.
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- The study investigated the effects of a 10mg/kg aqueous extract of Spergularia purpurea (SP) on cholesterol and triglyceride levels, as well as body weight, in normal and diabetic rats.
- In normal rats, SP led to a significant reduction in plasma cholesterol after both single and repeated doses, while triglyceride levels initially increased but then decreased with repeated dosing.
- In diabetic rats, SP also significantly lowered cholesterol levels with both dosing methods and reduced triglycerides after repeated administration, but it caused a notable decrease in body weight in both normal and diabetic groups after two weeks.