Coordinated prospective follow-up of Lynch syndrome is able to detect the majority of incident cancers.

Background: Lynch syndrome is one of the most common genetic predispositions to many cancers, most of which do not have a consensus recommendation for screening.

Aims: We studied in our region the value of a systematized and coordinated follow-up program for patients with Lynch syndrome on all organs at risk.

Methods: A multicenter prospective cohort evaluation was performed, from January 2016 to June 2021.