Regulatory mechanism of trichothecene biosynthesis in .

Among the genes involved in the biosynthesis of trichothecene ( genes), and encode a transcription factor with unique CysHis zinc finger domains and a regulatory protein with no consensus DNA-binding sequences, respectively. Although various chemical factors, such as nitrogen nutrients, medium pH, and certain oligosaccharides, are known to influence trichothecene biosynthesis in , the transcriptional regulatory mechanism of and genes is poorly understood. Particularly, culture medium pH is a major regulator in trichothecene biosynthesis in , but it is susceptible to metabolic changes posed by nutritional and genetic factors.