Publications by authors named "Naoto Wakabayashi"
Objective: To investigate the incidence of adverse events (AEs) following single and multiple administrations of I-131 metaiodobenzylguanidine (MIBG) therapy for inoperable pheochromocytomas and paragangliomas (PPGLs).
Methods: A single-center retrospective study was conducted on patients with inoperable PPGLs who underwent I-131 MIBG therapy between January 2000 and December 2020. A total of 28 patients with available electronic medical records were included.
Article Synopsis
- A convolutional neural network (CNN) model was developed to diagnose skull-base invasion by nasopharyngeal tumors using CT images and assessed for its diagnostic performance.
- The study involved 100 malignant nasopharyngeal tumor cases, split into training and test datasets, and aimed to improve diagnosis accuracy compared to expert radiologists.
- Results showed the CNN model achieved a diagnostic accuracy of 97.3%, outperforming two radiologists, and Grad-CAMs helped visualize the reasoning behind the model's predictions.
Objective: Silicon photomultiplier-based positron emission tomography/computed tomography (SiPM-PET/CT) has the superior spatial resolution to conventional PET/CT (cPET/CT). This head-to-head comparison study compared the images of physiological F-fluorodeoxyglucose (FDG) accumulation in small-volume structures between SiPM-PET/CT and cPET/CT in patients scanned with both modalities, and we investigated whether the thresholds that are reported to be useful for differentiating physiological accumulations from malignant lesions can also be applied to SiPM-PET/CT.
Methods: We enrolled 21 consecutive patients with head and neck malignancies who underwent whole-body FDG-PET/CT for initial staging or a follow-up evaluation (October 2020 to March 2022).
Article Synopsis
- Pheochromocytomas and paragangliomas (PPGLs) are rare tumors that produce hormones and can be treated with [131I] MIBG radionuclide therapy, with metabolic factors like metabolic tumor volume (MTV) and total lesion glycolysis (TLG) serving as potential poor prognostic indicators.
- A study of 20 patients evaluated their metabolic responses to this therapy using FDG-PET scans, classifying outcomes into categories like complete response and progressive disease, while also looking at overall survival differences between groups.
- The findings showed that both MTV and TLG were significant predictors of treatment response; however, urinary dopamine levels seemed to correlate with worse outcomes, while other clinical factors had no significant impact.
Newly developed simultaneous scanning photocurrent and luminescence microscopy was applied to ruthenium-based dye-sensitized solar cells (DSCs) comprising a cover glass photoanode with a 100 nm thick TiO2 layer. Using this, we have investigated the lateral variations of several parameters of these DSCs under short-circuit conditions. Simultaneous measurement of photocurrent and luminescence images for the same area of the DSC demonstrated submicrometric lateral resolution of our photocurrent microscopy, which is approximately 10 times better than the resolution of photocurrent microscopy used in past studies.
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