Number needed to treat and cost per remitter for biologic treatments of Crohn's disease in Japan.

Adalimumab, infliximab, and ustekinumab have been approved for patients with moderate-to-severe Crohn's disease in Japan. This study compared the relative efficacy and cost-effectiveness of adalimumab, infliximab, and ustekinumab in patients with Crohn's disease based on data from randomized controlled trials. Data were extracted from four phase 3 clinical trials: CHARM, NCT00445432, ACCENT I, and IM-UNITI.

Organizational culture affecting quality of care: guideline adherence in perioperative antibiotic use.

Objective: The objective of this work was to elucidate aspects of organizational culture associated with hospital performance in perioperative antibiotic prophylaxis using quantitative data in a multicenter and multidimensional study.

Design: Cross-sectional retrospective study using a survey data and administrative data.

Setting: Eighty-three acute hospitals in Japan.

Trends in hospital performance in acute myocardial infarction care: a retrospective longitudinal study in Japan.

Objective: To elucidate the hospital characteristics associated with hospital performance and time trends in acute myocardial infarction (AMI) care using multilevel multivariable analysis of longitudinal data.

Design: Retrospective longitudinal study.

Setting: One hundred and fourteen hospitals in Japan.

Association of geographical factors with administration of tissue plasminogen activator for acute ischemic stroke.

Background: Intravenous tissue plasminogen activator (tPA) is an effective treatment for acute ischemic stroke if administered within a few hours of stroke onset. Because of this time restriction, tPA administration remains infrequent. Ambulance use is an effective strategy for increasing tPA administration but may be influenced by geographical factors.

Quality of care and in-hospital resource use in acute myocardial infarction: evidence from Japan.

Objectives: To determine the association between quality of care in process and outcome measures and in-hospital resource use among patients admitted for acute myocardial infarction (AMI) in Japan.

Methods: We analyzed 23,512 AMI patients across 150 hospitals in Japan between April 2008 and March 2011. The exposure measure was inpatient hospital resource use, which was calculated from the sum of all hospital fees for healthcare services provided to AMI patients.