Publications by authors named "Naoto Fujioka"
The total synthesis of alcyonolide, an antitumor xenicn diterpenoid, has been achieved. The inverse electron demand hetero-Diels-Alder reaction using a dienophile possessing an electron-withdrawing group provided the endo adduct which included a condensed lactone and dihydropyran rings with the desired three stereogenic centers. After introduction of the side chain by the Negishi coupling, the lactone ring was opened to form a Weinreb amide.
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- The World Health Organization recommends using toxic equivalency factors (WHO-TEFs) for assessing the risks of brominated dioxins in aquatic ecosystems, despite limited toxicity data on fish.
- Researchers evaluated the toxicity of various brominated dioxins and furans against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) using Japanese medaka fish, discovering that certain brominated compounds caused harmful effects typical of dioxin exposure.
- The study found varying relative potencies (REPs) among different brominated dioxins, revealing that some had higher toxicity than TCDD, indicating a need for further research on mixed-halogenated dioxins and their environmental impact