Publications by authors named "Naomichi Sasaki"

Article Synopsis
  • * After more than two years, lung metastasis developed in both lungs despite the initial treatment, prompting the use of second-line chemotherapy with nedaplatin and docetaxel, which did not improve his condition.
  • * Nivolumab was then introduced as a third-line treatment, leading to the disappearance of the lung metastases after 6 cycles, but complications arose with pneumonia, highlighting the challenge of distinguishing between beneficial effects of treatment and drug-induced lung injury.
View Article and Find Full Text PDF

Minimally invasive completion gastrectomy is technically demanding and comprises a variety of procedures depending on the previous operation. We present herein a case of robot-assisted completion gastrectomy preserving the interposed jejunum in remnant gastric cancer following a proximal gastrectomy reconstructed by jejunal interposition. A 76-year-old, male patient experienced newly developed stage cT1bN0M0 gastric cancer in the distal remnant stomach 5 years after his initial proximal gastrectomy.

View Article and Find Full Text PDF

With the progress of replacement therapy for pancreatic endocrine and exocrine functions, the indications for a total pancreatectomy are expanding, and reports of multiple pancreatic metastases of renal cancer are on the rise. In the present, we investigated the utility of a total pancreatectomy for multiple pancreatic metastases of renal cancer. The subjects were 8 patients who underwent a total pancreatectomy for multiple pancreatic metastases of renal cancer between 2012 and 2021.

View Article and Find Full Text PDF

Peritoneal metastases of hepatocellular carcinoma (HCC) are occasionally observed, but rupture of such metastases is rare. We report a resected case with a single ruptured peritoneal HCC metastasis. A 57-year-old man with chronic hepatitis C underwent hepatic resection twice for hepatocellular carcinoma.

View Article and Find Full Text PDF

Background: Limited lung resection is generally believed to be available for lung adenocarcinoma in situ (AIS). At our institute, intraoperative hematoxylin-eosin staining of frozen-section slides is routinely performed for evaluating tumor invasiveness after partial resection to avoid excessive lung resection. This study aimed to evaluate the feasibility and usefulness of intraoperative frozen-section diagnosis of AIS.

View Article and Find Full Text PDF

Objective: Lymphatic permeation (LY) and vascular invasion (VI) are well-known as postoperative prognostic factors in non-small cell lung cancer (NSCLC). Some reports use the term "lymphovascular invasion (LVI)" in reference to the integration of LY and VI. The purpose in this study is to elucidate whether NSCLC with LY or VI can be labeled as LVI-positive NSCLC or it should be treated as an LY- or VI-positive tumor, respectively.

View Article and Find Full Text PDF

Background: Smoking can cause non-small cell lung cancer (NSCLC). However, the effects of preoperative smoking on tumor progression are not well-known. In addition, the duration of smoking cessation that can provide NSCLC patients with smoking history similar postoperative prognosis as that of nonsmokers remains unknown.

View Article and Find Full Text PDF

Even after complete resection, non-small cell lung cancer (NSCLC) shows preferential recurrence in the mediastinal lymph nodes, lungs, brain, bone, liver, and adrenal gland. However, the relationship between clinicopathological factors and recurrence patterns after resection has not been well-evaluated. Among 688 NSCLC cases with complete resection between 2004 and 2016, 233 cases recurred at our institute.

View Article and Find Full Text PDF
Article Synopsis
  • * The study used CRISPR-Cas9 techniques to remove the CTG repeat, which reduced RNA foci formation in patient-derived fibroblasts; however, a significant number of unintended mutations were detected.
  • * The findings suggest that while CRISPR-Cas9 is effective, it can cause off-target effects, so alternatives like CRISPR interference, which doesn't create double-strand breaks, should be explored for treatment.
View Article and Find Full Text PDF