Publications by authors named "Naomi Toyama"
The interleukin-6 signal regulates orthodontic tooth movement and pain.
Biochem Biophys Res Commun
December 2023
Orthodontic tooth movement (OTM) is accomplished by controlling the mechanical loading onto the bone around the roots of target teeth. The precise orthodontic force induces osteoclastic bone resorption on the compression side and osteoblastic bone formation on the tension side of the alveolar bone. Orthodontic intervention causes inflammation in the periodontal ligament (PDL), which manifests as acute pain.
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- Researchers created a GST-recombinant canine P53 fusion protein to identify anti-P53 antibodies in dogs with tumors.
- Out of 16 tumor serum samples, four tested positive for reactions with the fusion protein, while the other samples and controls did not show any reaction.
- Investigation of tumor tissues revealed a specific case with a p53 gene mutation that produced anti-P53 antibodies, indicating that these antibodies are linked to p53 mutations in tumor-affected dogs.