Publications by authors named "Naomi Shuwari"
Small extracellular vesicles (SEV) have attracted much attention both as mediators of intercellular communication and as drug delivery systems. In addition, recent studies have shown that SEV containing virus components and virus particles are released from virus-infected cells. Oncolytic viruses, which efficiently kill tumor cells by tumor cell-specific replication, have been actively studied as novel anticancer agents in clinical and preclinical studies.
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- PEGylated liposomes (PEG-liposomes) are effective for targeting tumors but face challenges due to physical obstacles within the tumor microenvironment.* -
- A study involving B16 melanoma mice showed that using oncolytic reovirus before administering PEG-liposomes significantly improved the delivery and distribution of the liposomes within the tumors, enhancing their effectiveness.* -
- The combination of reovirus and paclitaxel-loaded PEG-liposomes demonstrated a significant reduction in tumor growth, highlighting potential for clinical applications in combination therapies for cancer treatment.*
Background/aim: Oncolytic reovirus, which is a non-enveloped virus possessing a 10-segmented double-stranded RNA genome, has been anticipated as a novel class of antitumor agent. Hepatocellular carcinoma (HCC) is considered to be a target suitable for reovirus-mediated virotherapy. Transforming growth factor (TGF)-β plays an important role in the pathogenesis of HCC.
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