Publications by authors named "Naomi Otsuji"
This study describes an autopsy case of pancreatic/peripancreatic myeloid sarcoma in a 70-year-old man, initially presenting with obstructive jaundice. Pathologically, diffuse infiltration of round cells containing atypical nuclei with marked cleavage was observed mainly in the pancreas head, peripancreatic lymph nodes, spleen, bilateral lung, and bone marrow. Immunohistochemically, the tumor cells were negative for CD20, CD79a, CD3, CD5, c-kit, CD34, and TdT and positive for myeloperoxidase, CD33, CD68, and CD163.
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- The study investigates the prevalence of microsatellite instability (MSI) in triple-negative breast cancer (TNBC) and medullary carcinoma (MedCa), focusing on tumors with high densities of tumor-infiltrating lymphocytes (TILs).
- Despite expectations, all evaluated samples were found to be microsatellite stable, suggesting that MSI-H tumors are absent in these TIL-high breast cancers.
- The research also highlights the relationship between low MLH1 protein expression and increased levels of PD-L1 in immune cells, indicating that further exploration of DNA mismatch repair proteins could help identify patients who might benefit from immune-checkpoint inhibitors.