Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes.

Background: Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms.

Objective: This study aimed to identify and validate a sputum gene expression signature that discriminates asthma inflammatory phenotypes.

Methods: An asthma phenotype biomarker discovery study generated gene expression profiles from induced sputum of 47 asthmatic patients.