Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model.

Objective: Metformin is a polar positively charged compound. The aim of the study was to characterize its permeability across the human placenta using the ex vivo placental perfusion model.

Methods: Selected cotyledons from term placentas were cannulated and dually perfused.