Publications by authors named "Naomi Knavs"
Supercritical fluid chromatography for milligram preparation of enantiomers.
Biomed Chromatogr
January 2025
Article Synopsis
- Preparative chromatographic enantioseparation is the top method for isolating pure enantiomers during the early development of new drugs.
- Supercritical fluid chromatography was chosen for this process due to its advantages over traditional liquid chromatography.
- A total of 10 mg of each enantiomer of a new anti-inflammatory compound was successfully isolated, although some peak distortion occurred during testing, likely caused by the method of injection used.