Publications by authors named "Naomi J Fleury"
In previous preclinical studies, low (non-burning) doses of UV radiation (UVR) limited weight gain and metabolic dysfunction in mice fed with a high-fat diet. Here, we explored the effects of low-dose UVR on physical activity and food intake and mechanistic pathways in interscapular brown adipose tissue (iBAT). Young adult C57Bl/6J male mice, housed as individuals, were fed a high-fat diet and exposed to low-dose UVR (sub-oedemal, 1 kJ/m2 UVB, twice-a-week) or 'mock' treatment, with or without running wheel access (2 h, for 'moderate' physical activity) immediately after phototherapy.
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- The study investigates how low-dose ultraviolet radiation (UVR) impacts metabolic health and obesity, showing that regular UVR exposure reduces weight gain and diabetes symptoms in mice on a high-fat diet through mechanisms involving nitric oxide release from the skin.
- Researchers used a special type of mouse that helps track certain proteins (UCP-1) to monitor the effects of UVR on weight gain and fat metabolism, finding that UVR exposure improved glucose tolerance and reduced fat accumulation in the liver.
- While UVR significantly increased UCP-1 expression in mice on a low-fat diet, its effects were not seen in those on a high-fat diet, indicating that the metabolic benefits of UVR may depend on