Publications by authors named "Naomi E Tinkelman"
Article Synopsis
- Exposure to low to moderate arsenic levels in mothers is linked to an increased risk of type 2 diabetes (T2D) and metabolic health issues in their adult offspring, particularly in American Indian communities.
- The study investigated the relationship between maternal DNA methylation (a molecular marker) and T2D-related outcomes in these offspring, finding specific gene sites (CpGs) associated with insulin resistance and T2D.
- Results indicated that the offspring's body fat levels played a more significant role in influencing the health effects of maternal DNA methylation than the mother's own weight, highlighting the potential use of epigenetic markers for assessing health risks due to arsenic exposure.
Experimental and prospective epidemiologic evidence suggest that arsenic exposure has diabetogenic effects. However, little is known about how family exposure to arsenic may affect risk for type 2 diabetes (T2D)-related outcomes in adulthood. We evaluated the association of both maternal and offspring arsenic exposure with fasting glucose and incident T2D in 466 participants of the Strong Heart Family Study.
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