Publications by authors named "Naomi D Chrispijn"
Polycomb group (PcG) proteins are transcriptional repressors that are important regulators of cell fate during embryonic development. Among them, Ezh2 is responsible for catalyzing the epigenetic repressive mark H3K27me3 and is essential for animal development. The ability of zebrafish embryos lacking both maternal and zygotic to form a normal body plan provides a unique model for comprehensively studying Ezh2 function during early development in vertebrates.
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- The Polycomb group (PcG) protein family, particularly Rnf2, was studied in zebrafish to understand its impact on gene regulation related to heart development.
- Researchers found that without Rnf2, genes normally kept in check became overactive, especially genes that should be regulated by Rnf2.
- In rnf2 mutant hearts, there was a notable increase in heart transcription factors and a decrease in genes specific to heart chambers, suggesting that the lack of Rnf2 disrupts normal heart development and function.
Polycomb Group (PcG) genes are transcriptional repressors that are described to be important during development and differentiation. There is significant interest in PcGs proteins because of their role in stem cell biology and tumorigenesis. In this study we characterize the expression of a selection of PcG genes in the adult germline of zebrafish and during embryogenesis.
View Article and Find Full Text PDFPolycomb group (PcG) proteins are transcriptional repressors of numerous genes, many of which regulate cell cycle progression or developmental processes. We used zebrafish to study Enhancer of zeste homolog 2 (Ezh2), the PcG protein responsible for placing the transcriptional repressive H3K27me3 mark. We identified a nonsense mutant of ezh2 and generated maternal zygotic (MZ) ezh2 mutant embryos.
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