Publications by authors named "Naomi B Boekel"
Purpose: Breast cancer (BC) treatment can induce adverse events, such as cardiovascular disease (CVD). Defective DNA repair, as in carriers of BRCA1/2 pathogenic variants (BRCA1/2pv), may contribute to CVD risk. We aimed to study if female BRCA1/2pv carriers are more sensitive to develop CVD after BC treatment than BC patients without a known BRCA1/2pv.
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- Hodgkin lymphoma (HL) survivors who receive chest radiotherapy are at greater risk for developing breast cancer (BC) and facing additional cardiovascular disease (CVD) complications.
- A study comparing BC patients with prior HL treatment to those with no prior HL showed that the former received less aggressive cancer treatments and had significantly higher mortality rates.
- The findings indicate that clinicians should consider the increased risk of CVD and poorer BC outcomes when treating HL survivors who develop breast cancer.
Exposure of the heart and cardiac valves in women irradiated for breast cancer 1970-2009.
Clin Transl Radiat Oncol
September 2022
Purpose: To describe cardiac exposure from breast cancer radiotherapy regimens used during 1970-2009 for the development of dose-response relationships and to consider the associated radiation-risks using existing dose-response relationships.
Material And Methods: Radiotherapy charts for 771 women in the Netherlands selected for case control studies of heart disease after breast cancer radiotherapy were used to reconstruct 44 regimens on a typical CT-dataset. Doses were estimated for the whole heart (WH), left ventricle (LV) and cardiac valves.
Purpose: Anthracyclines and trastuzumab can increase the risk of heart failure (HF), but long-term cardiotoxicity data in breast cancer (BC) patients treated at younger ages are limited. Furthermore, it is unknown whether aromatase inhibitors are associated with HF risk.
Methods: HF risk was studied in a multicenter cohort of BC survivors treated during 2000-2009, at age < 61 years.
Background And Purpose: Breast cancer patients treated with radiotherapy are at increased risk of subsequent acute coronary syndromes (ACS). We aimed to study if radiotherapy also influences the prognosis of these ACS.
Materials And Methods: We included all 398 patients diagnosed with ACS following radiotherapy from our hospital-based cohort of early breast cancer patients aged <71 years, treated 1970-2009.
Background: We aimed to develop dose-response relationships for heart failure (HF) following radiation and anthracyclines in breast cancer treatment, and to assess HF associations with trastuzumab and endocrine therapies.
Methods And Results: A case-control study was performed within a cohort of breast cancer survivors treated during 1980-2009. Cases (n = 102) had HF as first cardiovascular diagnosis and were matched 1:3 on age and date of diagnosis.
Radiation Dose-Response for Risk of Myocardial Infarction in Breast Cancer Survivors.
Int J Radiat Oncol Biol Phys
March 2019
Purpose: Previous reports suggest that radiation therapy for breast cancer (BC) can cause ischemic heart disease, with the radiation-related risk increasing linearly with mean whole heart dose (MWHD). This study aimed to validate these findings in younger BC patients and to investigate additional risk factors for radiation-related myocardial infarction (MI).
Methods And Materials: A nested case-control study was conducted within a cohort of BC survivors treated during 1970 to 2009.
Background: Improved breast cancer (BC) survival and evidence showing beneficial effects of internal mammary chain (IMC) irradiation underscore the importance of studying late cardiovascular effects of BC treatment.
Methods: We assessed cardiovascular disease (CVD) incidence in 14,645 Dutch BC patients aged <62 years, treated during 1970-2009. Analyses included proportional hazards models and general population comparisons.
Cardiovascular Disease Risk in a Large, Population-Based Cohort of Breast Cancer Survivors.
Int J Radiat Oncol Biol Phys
April 2016
Article Synopsis
- A study was conducted on over 70,000 breast cancer survivors treated since 1989 to analyze their risk of cardiovascular disease (CVD) compared to the general population.
- The findings revealed that breast cancer patients had a slightly lower overall CVD mortality risk but a higher risk specifically for valvular heart disease, particularly those who received left-sided radiation therapy after mastectomy.
- Young patients diagnosed under 50 showed increased CVD risks related to specific radiation treatments and chemotherapy that started in 1997, indicating the importance of considering treatment history when assessing long-term health impacts.
Background: Recent concerns about potential overdiagnosis and overtreatment of ductal carcinoma in situ of the breast (DCIS) render evaluation of late effects of treatment, such as cardiovascular disease (CVD), of great importance. We studied cardiovascular morbidity and mortality in a large population-based cohort of DCIS patients.
Methods: Data on all incident DCIS case patients in the Netherlands between 1989 and 2004 who were diagnosed before the age of 75 years were obtained (n = 10468).
Background And Purpose: It has been established that radiotherapy can increase cardiovascular disease (CVD) risk. Genetic variants, which play a role in the tissue, damage response and angiogenesis regulating TGFβ pathway might give us insight into the mechanisms underlying radiation-induced CVD. We examined the effects of two polymorphisms, TGFβ1 29C>T and PAI-1 5G>4G, on CVD incidence.
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