Publications by authors named "Naoko Yasumori"
Article Synopsis
- The study assessed how proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) affect the effectiveness and safety of dasatinib in treating chronic phase chronic myeloid leukemia (CP-CML).
- Among 73 patients, those receiving PPIs or H2RAs alongside dasatinib showed a significantly higher major molecular response (100%) than those on dasatinib alone (45.1%).
- Additionally, patients on the combination treatment experienced fewer discontinuations of dasatinib due to side effects, indicating that PPIs and H2RAs not only enhance dasatinib's efficacy but also help manage its side effects.
Elevations of urinary pH may lower vancomycin serum concentration.
Int J Clin Pharmacol Ther
December 2015
Objective: This study investigated endogenous factors that may increase the elimination of vancomycin (VCM) in adult methicillin-resistant Staphylococcus aureus (MRSA) patients with pneumonia.
Methods: 48 patients (32 men and 16 women) admitted to the National Hospital Organization Kumamoto Medical Center for pneumonia due to MRSA were evaluated. VCM (500 - 2,000 mg/dose) was administered intravenously for 60 - 120 min at 8- - 12-h intervals.