Publications by authors named "Naoko Tago"
Article Synopsis
- The study highlights the limitations of traditional liver cancer markers, α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), particularly in early-stage hepatocellular carcinoma (HCC) and in patients with liver issues.
- Researchers evaluated serum protein kinase C delta (PKCδ) as a potential new biomarker for HCC diagnosis and found it to have high sensitivity and specificity, even in early stages of the disease.
- PKCδ levels remained consistent regardless of hepatitis C virus (HCV) status, liver injury, or warfarin treatment, making it a promising alternative to conventional markers for more accurate HCC detection.
Extended-synaptotagmin 1 (E-Syt1) is an endoplasmic reticulum membrane protein that is involved in cellular lipid transport. Our previous study identified E-Syt1 as a key factor for the unconventional protein secretion of cytoplasmic proteins in liver cancer, such as protein kinase C delta (PKCδ); however, it is unclear whether E-Syt1 is involved in tumorigenesis. Here, we showed that E-Syt1 contributes to the tumorigenic potential of liver cancer cells.
View Article and Find Full Text PDFProtein secretion in cancer cells defines tumor survival and progression by orchestrating the microenvironment. Studies suggest the occurrence of active secretion of cytosolic proteins in liver cancer and their involvement in tumorigenesis. Here, we investigated the identification of extended-synaptotagmin 1 (E-Syt1), an endoplasmic reticulum (ER)-bound protein, as a key mediator for cytosolic protein secretion at the ER-plasma membrane (PM) contact sites.
View Article and Find Full Text PDFBackgrounds And Aims: Hepatocellular carcinoma (HCC) is the most common cancer with a poor prognosis. Identification of an alternative biomarker that can detect early-stage and conventional tumor marker-negative HCC is urgently needed. We found that protein kinase C delta (PKCδ) is specifically secreted from HCC cell lines into extracellular space and contributes to tumor development and that its serum levels were elevated in HCC patients.
View Article and Find Full Text PDFObjective: Hematopoietic stem cells are kept in a quiescent state in the hypoxic area of the bone marrow, which is essential for hematopoietic stem cell maintenance. However, when and how hematopoietic stem cells acquire their hypoxic state and maintain quiescence has not been fully elucidated. The aim of this study was to understand this process in human hematopoietic stem cells after bone marrow transplantation.
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