Oxidation of substituted toluenes with molecular oxygen in the presence of N,N',N' '-trihydroxyisocyanuric acid as a key catalyst.

N,N',N' '-Trihydroxyisocianuric acid (THICA) was found to be a very efficient catalyst for the oxidation of alkylbenzenes with dioxygen. Thus, a variety of meta- and para-substituted toluenes bearing an electron-withdrawing substituent such as cyanotoluene, chlorotoluene, and toluic acid under O(2) (1 atm) in the presence of THICA (5 mol %) and Co(OAc)(2) (0.5 mol %) at 100 degrees C were smoothly oxidized to the corresponding benzoic acids in almost quantitative yields.