Publications by authors named "Naoko Mitsutomi"
Article Synopsis
- The central nervous system's glial cells are primarily made up of astrocytes, whose impairment is linked to various disorders.
- Researchers are trying to explore how to analyze astrocytes derived from induced pluripotent stem cells (iPSCs) to understand their roles in disease conditions.
- By modifying differentiation protocols and evaluating functions like cytokine release and calcium influx, the study developed a method to model astrocyte-related diseases, specifically Alexander disease, using iPSC-derived astrocytes.
A practical asymmetric synthesis of both enantiomers of the immunosuppressive FTY720-phosphate (2) was accomplished, and the enantiomers were pharmacologically evaluated. Several lipases showed considerable activity and enantioselectivity for O-acylation of N-acetyl FTY720 (3) or N-benzyloxycarbonyl FTY720 (7) in combination with vinyl acetate or benzyl vinyl carbonate as the acyl donors. The synthesis using the lipase-catalyzed acylation as the key step produced the enantiomerically pure (>99.
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