Publications by authors named "Naoko H Moriya"
Nitric oxide (NO) is an important chemical messenger controlling many physiological functions, involving cell proliferation, and differentiation. The purpose of this study was to investigate the effect of NO on adipocyte differentiation using a murine preadipocyte cell line, 3T3-L1. The treatment with a NO donor, 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene (NOC18), reduced some markers of adipocyte differentiation such as glycerol-3-phosphate dehydrogenase activity, and intracellular lipid accumulation.
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- The study examined how activin A and follistatin influence the differentiation of bovine preadipocytes isolated from Japanese Black steers' adipose tissue.
- Activin A was found to suppress key differentiation markers, impacting the expression of critical genes like PPAR gamma and C/EBP alpha, while follistatin could counteract this inhibitory effect.
- The results suggest that activin A may inhibit preadipocyte differentiation by affecting gene transcription, and that both activin A and myostatin may play a role in regulating this process in bovines.