Publications by authors named "Naoki Numajiri"
Article Synopsis
- The study assesses the economic implications of advanced therapies (biologics and Janus kinase inhibitors) for treating ulcerative colitis in Japan, focusing on cost-effectiveness.
- A cost per responder model was developed to compare the expenses of various treatments based on clinical outcomes for both biologic-naïve and biologic-exposed patients.
- Upadacitinib showed favorable cost-effectiveness in achieving clinical response and remission, outperforming other treatments except in one specific case for biologic-exposed patients.
Nitric oxide (NO) physiologically regulates numerous cellular responses through S-nitrosylation of protein cysteine residues. We performed antibody-array screening in conjunction with biotin-switch assays to look for S-nitrosylated proteins. Using this combination of techniques, we found that phosphatase with sequence homology to tensin (PTEN) is selectively S-nitrosylated by low concentrations of NO at a specific cysteine residue (Cys-83).
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