Peripersonal space (PPS), the space immediately surrounding one's body, contributes to interactions with the external environment. Previous studies have demonstrated that PPS expands during whole-body self-motion. Furthermore, motor and proprioceptive information contributes to this phenomenon.
View Article and Find Full Text PDFColorectal cancer (CRC) resulting from chronic inflammation is a crucial issue in patients with inflammatory bowel disease (IBD). Although many reports established that intestinal resident CX3CR1 macrophages play an essential role in suppressing intestinal inflammation, their function in colitis-related CRC remains unclear. In this study, we found that colonic CX3CR1 macrophages, which were positive for MHC-II, F4/80 and CD319, promoted colitis-associated CRC.
View Article and Find Full Text PDFAnkylosing spondylitis (AS), primary sclerosing cholangitis (PSC), and autoimmune pancreatitis (AIP) are known as extraintestinal manifestations (EIMs) of ulcerative colitis (UC). A 74-year-old Japanese man visited our hospital because of white stool. He had been diagnosed with AS when he was 30 years old, and he was HLA-B27-positive.
View Article and Find Full Text PDFNihon Shokakibyo Gakkai Zasshi
March 2024
A 59-year-old man presented to our hospital with a chief complaint of epigastric pain. Pertinent history included a distal gastrectomy for gastric cancer and alcohol dependence. He underwent contrast-enhanced computed tomography (CT) and esophagogastroduodenoscopy, which led to a diagnosis of esophageal cancer (cT2N2M1, stage IVb).
View Article and Find Full Text PDFAlthough motor imagery and working memory (WM) appear to be closely linked, no previous studies have demonstrated direct evidence for the relationship between motor imagery and WM abilities. This study investigated the association between WM and gait motor imagery and focused on the individual differences in young adults. This study included 33 participants (mean age: 22.
View Article and Find Full Text PDFThe space immediately around the body, referred to as the peripersonal space (PPS), plays a crucial role in interactions with external objects and in avoiding unsafe situations. This study aimed to investigate whether the size of the PPS changes depending on direction, with a particular focus on the disparity between the front and rear spaces. A vibrotactile stimulus was presented to measure PPS while a task-irrelevant auditory stimulus (probe) approached the participant.
View Article and Find Full Text PDFIf voluntary action is followed by an effect with a short time delay, the time interval between action and effect is often perceived to be shorter than it actually is. This perceptual time compression is termed intentional binding or temporal binding. We investigated age-related changes in adulthood considering temporal binding and its dependence on action body parts (i.
View Article and Find Full Text PDFWhen a voluntary action is followed by an effect after a short delay, the time distance between the action and its effect is perceived to be shorter than the actual time distance. This phenomenon is known as intentional binding (IB). We investigated the influence of presentation of an additional effect on IB between the action and the target effect, and investigated the influence of the presentation timing of the additional effect.
View Article and Find Full Text PDFPrevious studies have shown that space perception around the body is altered by self-motion, and that several self-motion cues from different modalities, including vision, proprioception, the vestibular system, and the motor system (motor commands) contribute to it. However, studies on how online self-motion information affects the perception of a passable width of a narrow aperture is largely overlooked by existing literature. Therefore, this study investigated this issue during virtual bike riding.
View Article and Find Full Text PDFThe space immediately around the body, known as the peripersonal space (PPS), plays an important role in interactions with the environment. Specific representations are reported to be constructed in the brain. PPS expansion reportedly occurs during whole-body self-motions, such as walking; however, little is known regarding how dynamic cues in proprioceptive/motor information contribute to such phenomena.
View Article and Find Full Text PDFThe introduction of anti-inflammatory therapies has enabled substantial improvement of disease activity in patients with inflammatory bowel diseases (IBD). However, IBD can lead to serious complications such as intestinal fibrosis and colorectal cancer. Therefore, novel therapies reducing the development of these complications are needed.
View Article and Find Full Text PDFExp Brain Res
January 2021
Peripersonal space (PPS), which refers to space immediately around an individual's body, plays an important role in interacting with external objects and avoiding unsafe situations. Studies suggest that, during self-motion perception, PPS expands in the direction in which a person perceives himself/herself to be traveling. In the present study, we built on this by investigating, using visually induced self-motion (vection), how visual self-motion information modulates PPS representation.
View Article and Find Full Text PDFAdoption of interventional endoscopic procedures is increasing with increasing prevalence of diseases. However, medical radiation exposure is concerning; therefore, radiation protection for medical staff is important. However, there is limited information on the usefulness of an additional lead shielding device during interventional endoscopic procedures.
View Article and Find Full Text PDFIntestinal fibrosis is a serious complication in inflammatory bowel disease (IBD). Despite the remarkable success of recent anti-inflammatory therapies for IBD, incidence of intestinal fibrosis and need for bowel resection have not significantly changed. To clarify the contribution of haematopoietic-derived cells in intestinal fibrosis, we prepared bone marrow (BM) chimeric mice (chimeras), which were reconstituted with BM cells derived from enhanced green fluorescent protein (EGFP)-transgenic mice or CC chemokine receptor 2 (CCR2)-deficient mice.
View Article and Find Full Text PDFBackground: There have been few reports about the late effects of disconnected pancreatic duct syndrome (DPDS). Although few reports have described the recurrence interval of pancreatitis, it might be rare for recurrence to occur more than 5 years later. Herein, we describe a case of recurrence in an 81-year-old man after the treatment of walled-off necrosis (WON) with pancreatic transection 7 years ago.
View Article and Find Full Text PDFBackground: Although Merkel cell polyomavirus (MCPyV) has the potential to cause Merkel cell carcinoma (MCC), it is also found in the normal skin of healthy individuals. However, the mechanism for transformation of MCPyV to an oncogenic form is unknown.
Objectives: To investigate the levels of MCPyV infection in the normal skin patients with MCC compared with those in a control cohort.
To clarify whether the new Japanese glomerular filtration rate (eGFR) equation was able to accurately determine the initial and individualized dosage adjustment concentrations of vancomycin (VCM), the predictive performance for VCM concentrations using the eGFR and Cockcroft-Gault (CG) equations was compared. Data were retrospectively collected from clinical records of 90 patients with MRSA infection whose trough and peak VCM concentrations had been determined. The predicted VCM initial and individualized dosage adjustment concentrations were performed with the 2-compartment linear model using pharmacokinetic parameter means and their individual values via Bayesian estimation, respectively.
View Article and Find Full Text PDF