Redox photosensitisers (PSs) play essential roles in various photocatalytic reactions. Herein, we synthesised new redox PSs of 1 : 1 supramolecules that comprise a ring-shaped Re(i) tetranuclear complex with 4+ charges and a Keggin-type heteropolyoxometalate with 4- charges. These PSs photochemically accumulate multi-electrons in one molecule (three or four electrons) in the presence of an electron donor and can supply electrons with different reduction potentials.
View Article and Find Full Text PDFFimbrin forms bundles of parallel actin filaments in filopodia, but it remains unclear how fimbrin forms well-ordered bundles. To address this issue, we focused on the cooperative interaction between the actin-binding domain of fimbrin and actin filaments. First, we loosely immobilized actin filaments on a glass surface via a positively charged lipid layer and observed the binding of GFP-fused actin-binding domain 2 of fimbrin using fluorescence microscopy.
View Article and Find Full Text PDFLipid distribution in the liver provides crucial information for diagnosing the severity of fatty liver and fatty liver-associated liver cancer. Therefore, a noninvasive, label-free, and quantitative modality is eagerly anticipated. We report near-infrared hyperspectral imaging for the quantitative visualization of lipid content in mouse liver based on partial least square regression (PLSR) and support vector regression (SVR).
View Article and Find Full Text PDFThe diagnosis of gastrointestinal stromal tumor (GIST) using conventional endoscopy is difficult because submucosal tumor (SMT) lesions like GIST are covered by a mucosal layer. Near-infrared hyperspectral imaging (NIR-HSI) can obtain optical information from deep inside tissues. However, far less progress has been made in the development of techniques for distinguishing deep lesions like GIST.
View Article and Find Full Text PDFContactless thermal imaging generally relies on mid-infrared cameras and fluorescence imaging with temperature-sensitive phosphors. Fluorescent thermometry in the near-infrared (NIR) region is an emerging technique for analysing deep biological tissues but still requires observation depth calibration. We present an NIR fluorescence time-gated imaging (TGI) thermometry technology based on fluorescence lifetime, an intrinsic fluorophore time constant unrelated to observation depth.
View Article and Find Full Text PDFStabilization by a silyl group on the methylene carbon and a diamine ligand led to the isolation of gem-dichromiomethane species. X-ray crystallography confirmed the identity of the structure of this rare example of reactive gem-dimetalloalkane species. The isolated gem-dichromiomethane complex acted as a storable silylmethylidene carbene equivalent, with reactivity that could be changed dramatically upon addition of a Lewis acid (ZnCl) and a base (TMEDA) to promote both silylalkylidenation of polar aldehydes and silylcyclopropanation of nonpolar alkenes.
View Article and Find Full Text PDFTreatment of gem-di(iodozincio)methane with pyridine or diamine derivatives resulted in the isolation of a storable gem-di(iodozincio)methane species. Use of the sterically bulky bipyridine ligand gave a gem-di(iodozincio)methane complex, which allowed the first X-ray structural analysis of such species. This work represents a rare example of the isolation of an organometallic reactive species in Schlenk equilibrium and thus provides new insight into the design of efficient and storable organometallic reagents.
View Article and Find Full Text PDFThe reaction of 2-(2-arylphenyl)vinyl ethers in the presence of a catalytic amount of bismuth(III) triflate gave substituted phenanthrenes in excellent yields under mild reaction conditions. The reaction was also applied to the construction of other polycyclic aromatic hydrocarbons (PAHs), such as chrysene, helicene, and pyrene having a phenanthrene backbone, via regioselective cyclization. This method has the advantages of easy availability of the cyclization precursors, operational simplicity, and high reaction efficiency.
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