Publications by authors named "Naoki Hidaka"
Cerebellar climbing fibers convey sensorimotor information and their errors, which are used for motor control and learning. Furthermore, they represent reward-related information. Despite such functional diversity of climbing fiber signals, it is still unclear whether each climbing fiber conveys the information of single or multiple modalities and how the climbing fibers conveying different information are distributed over the cerebellar cortex.
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- The cerebellum has a unique modular structure with climbing fiber (CF) projections that vary based on specific marker expression, but the functional implications of these projections remain unclear.
- Using two-photon calcium imaging in mice, researchers examined how CF inputs in cerebellar module Crus II affect behavior during an auditory task, revealing different CF signal patterns in medial and lateral modules.
- The study shows that medial module CF signals are linked to quick motor initiation and reward responses, while lateral module signals are associated with no-go cues and rewards, suggesting that distinct CF inputs contribute to different aspects of goal-directed behavior.