Publications by authors named "Naoki Hama"

Article Synopsis
  • Capicua transcriptional repressor-double homeobox 4 sarcoma (CDS) is a rare and aggressive soft tissue tumor, which in this case was found in the stomach and invaded surrounding organs.
  • A 48-year-old male had a large tumor diagnosed initially as neuroendocrine carcinoma, but after extensive imaging and biopsy, it was confirmed as CDS.
  • The tumor was successfully removed through a multivisceral resection, and the patient had a good recovery, marking this as the first detailed report of a gastric CDS being surgically managed.
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Background: Laugier's hernia is a very rare atypical femoral hernia and is challenging to diagnose preoperatively. Herein, we report a rare case of inguinal and Laugier's hernias treated with laparoscopic transabdominal preperitoneal repair.

Case Presentation: A 63-year-old man was admitted to our hospital with right groin swelling for 4 years.

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Refractory gastroesophageal reflux disease can develop after proximal gastrectomy and esophagogastrostomy. We introduce a new method that combines distal gastrectomy and Roux-en-Y reconstruction to treat refractory reflux esophagitis in patients who have undergone proximal gastrectomy and esophagogastric anastomosis reconstruction. This novel method may be useful not only for alleviating the symptoms of gastroesophageal reflux disease but also for preventing future esophageal malignancies arising from long-term reflux esophagitis.

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A 78-year-old man was diagnosed with lymph node metastasis 2 months after surgery for gastric neuroendocrine carcinoma. He received chemotherapy(CDDP plus CPT-11)and showed partial response(PR)after 3 courses of the regimen. Serum CEA increased 5 months after surgery, thus nab-paclitaxel plus ramucirumab was administered.

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A 78-year-old man was diagnosed as HER2-positive unresectable advanced gastric cancer(cT4aN3M1[LYM], Stage Ⅳ). After 2 courses of first-line chemotherapy(S-1 plus oxaliplatin plus trastuzumab), PR was achieved. The treatment could not be continued due to adverse events after 5 courses, thus second-line chemotherapy was conducted.

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In transplantation using allogeneic induced pluripotent stem cells (iPSCs), strategies focused on major histocompatibility complexes were adopted to avoid immune rejection. We showed that minor antigen mismatches are a risk factor for graft rejection, indicating that immune regulation remains one of the most important issues. In organ transplantation, it has been known that mixed chimerism using donor-derived hematopoietic stem/progenitor cells (HSPCs) can induce donor-specific tolerance.

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The study presents the case of a 71-year-old woman who visited a nearby hospital for epigastric pain and weight loss. A CT scan showed a mass in the gallbladder, and the CEA level was high, so she was referred to our hospital for further investigation. Abdominal US, CT, and MRI suggested gallbladder cancer with para-aortic metastasis, and the histological findings on the EUS-FNA confirmed the diagnosis.

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A 52-year-old man underwent total gastrectomy for gastric cancer and chemoradiotherapy for thoracic paraaortic lymph node metastasis. He also underwent esophageal stent implantation for stenosis. He was admitted to our hospital with fever and breathing difficulty and was diagnosed with infectious pericarditis.

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Article Synopsis
  • - The study investigates the role of interleukin (IL)-34 in ovarian cancer, particularly how it contributes to the resistance against PARP inhibitor therapy in BRCA1-related cases, indicating that high levels of IL-34 are linked to poorer patient outcomes.
  • - Using data from The Cancer Genome Atlas and CRISPR-Cas9 in mouse models, researchers found that IL-34 is an independent factor that shortens overall survival and interferes with the anti-tumor effects of PARP inhibitors by impacting the tumor microenvironment.
  • - The findings highlight IL-34's role in creating an immunosuppressive environment that aids tumor growth and resistance to treatment, suggesting it should be considered a potential therapeutic target in ovarian
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Purpose: To evaluate the efficacy and safety of the enhanced recovery after surgery (ERAS) protocol and quantify the impact of each ERAS item on postoperative outcomes.

Methods: We used a generalized linear model to compare 289 colorectal cancer patients treated with the ERAS protocol between June, 2015 and April, 2021, with 99 colorectal cancer patients treated with the conventional colorectal surgery pathway between April, 2014 and June, 2015.

Results: The median length of hospital stay (LOHS) was significantly shorter in the ERAS group, at 9 days (range 3-104 days) vs.

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The patient was a 72-year-old man with a history of pancreatic cancer and IPMA treated with distal pancreatectomy. He had recurrence-free period after adjuvant chemotherapy with S-1. But 6 years after the surgery, a diameter of 1 cm mass was noted in the remnant pancreas on MRI examination after hepatocellular carcinoma treatment.

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Article Synopsis
  • - Case 1 involved a 51-year-old man diagnosed with a gastric GIST, who underwent successful treatment with imatinib leading to significant tumor shrinkage and laparoscopic surgery; he remained recurrence-free for 4 years post-operation.
  • - Case 2 was a 68-year-old man with a suspected gastric GIST, who also received imatinib but faced some side effects that required dosage adjustment; despite this, he experienced tumor reduction and underwent successful laparoscopic surgery.
  • - Both cases demonstrate that neoadjuvant imatinib therapy can effectively shrink large gastric GISTs, allowing for safe and complete surgical resection.
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Case 1: A 67-year-old male had a type 1 tumor in the stomach with a lymph node metastasis 50 mm in size. He was diagnosed with cT4aN(+)M0, cStage Ⅲ and received preoperative docetaxel plus oxaliplatin plus S-1(DOS)therapy. After 3 courses of the regimen, the patient underwent laparoscopic total gastrectomy.

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A 75-year-old man was admitted to our hospital for breathing difficulty. CT showed a 20 cm mass with clear boundaries and internal non-uniformity, which we suspected to be a gastrointestinal stromal tumor(GIST). Surgical resection was been considered to be risky because the mass was close to surrounding organs, such as the stomach, liver and diaphragm.

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A 65-year-old man with 1 month of general malaise was admitted to our hospital. Thoracoabdominal CT showed that the supra-clavicular, sub-carina, and para-aortic lymph nodes were swelling. Upper gastrointestinal endoscopy revealed 2 type 1 tumors at the esophagogastric junction, and the biopsy showed Group 5, well to moderately differentiated adenocarcinoma.

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Article Synopsis
  • * Following surgery, including Hartmann's procedure and partial resections, the patient's pathology revealed both sigmoid colon cancer and a gastrointestinal stromal tumor, with subsequent chemotherapy shrinking some liver tumors but also allowing others to grow.
  • * A later surgery removed the remaining liver tumors, confirming that some were adenocarcinomas from the colon cancer, while others originated from the gastrointestinal stromal tumor, highlighting the complexity of multiple primary tumors and their metastases.
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Article Synopsis
  • Around 8,300 hemophiliacs are registered in Japan, but there's a lack of comprehensive data on hepatobiliary and pancreatic surgeries (HBPS) in these patients, prompting this study to explore their current surgical outcomes.
  • The study analyzed 49 hemophiliac patients who underwent HBPS between 2007 and 2017, focusing on their backgrounds, types of hemophilia, surgical procedures, and any complications encountered post-surgery.
  • Results showed that common procedures included limited resections for liver cancers and standard operations for pancreatic cancers, with complication rates for hemophiliac patients not significantly higher than those in the general population when surgeries are conducted at specialized centers.
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Post-transplant patients reportedly have a higher risk of de novo neoplasms. However, intraductal papillary mucinous neoplasm (IPMN) of the native pancreas after pancreas transplantation (PTx) has not been well investigated. The choice of treatment, especially invasive treatment, for de novo neoplasms in transplant patients should consider their impaired immunity.

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Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, and multimodal strategies, such as surgery plus neoadjuvant chemotherapy (NAC)/adjuvant chemotherapy, have been attempted to improve survival in patients with localized PDAC. To date, there is one prospective study providing evidence for the superiority of a neoadjuvant strategy over upfront surgery for localized PDAC. However, which NAC regimen is optimal remains unclear.

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During the follow‒up of Vater papillary adenoma, a 74‒year‒old man was admitted to our hospital with a chief complaint of upper abdominal pain and diagnosed as cholangitis with obstructive jaundice. Cholestasis had been considered to be caused by papillary adenoma, however, EUS exam showed continuous bile duct wall irregularity from papilla of Vater. So we diagnosed as papillary carcinoma with extension to the distal bile duct.

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Article Synopsis
  • - Researchers found that IL-34 plays a role in resistance to immune therapies in mice and wanted to see if this holds true in human tumors as well.
  • - They used a specific method to select an IL-34-neutralizing antibody and transplanted human tumor tissue that expresses both IL-34 and PD-L1 into mice that have an immune system similar to humans.
  • - This patient-derived xenograft model is designed to study how neutralizing IL-34 affects the immune response when combined with immune checkpoint blockade in human cancers, with more detailed information available from Hama et al. (2020).
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Although the standard treatment for intramucosal esophageal cancer without lymph node metastasis is endoscopic submucosal dissection (ESD), we sometimes encounter patients who are not able to undergo a transoral endoscopic examination. Here, we report a surgical procedure consisting of transgastric retrograde ESD to treat early esophageal cancer (T1a-EP, N0, M0) because of a stricture after hypopharyngeal cancer surgery. This retrograde ESD procedure can be a safe and effective treatment option for early esophageal cancer.

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Primary duodenal carcinoma is a rare disease among gastrointestinal malignancies and has little evidence. We evaluated retrospectively the treatment status of 16 cases of primary duodenal carcinoma in our hospital between 2010 and 2019. The median age was 72(58-88)years and 63% of patients were male, and Each stage were Stage 0 in 4 cases, Stage Ⅰ in 1 case, Stage ⅢA in 2 cases, Stage ⅢB in 3 cases, and Stage Ⅳ in 6 cases(UICC 8th edition).

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Interleukin-34 (IL-34) is an alternative ligand to colony-stimulating factor-1 (CSF-1) for the CSF-1 receptor that acts as a key regulator of monocyte/macrophage lineage. In this study, we show that tumor-derived IL-34 mediates resistance to immune checkpoint blockade regardless of CSF-1 existence in various murine cancer models. Consistent with its immunosuppressive characteristics, the expression of IL-34 in tumors correlates with decreased frequencies of cellular (such as CD8 and CD4 T cells and M1-biased macrophages) and molecular (including various cytokines and chemokines) effectors at the tumor microenvironment.

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