Publications by authors named "Naohiro Hirano"
Article Synopsis
- Liquid biopsy (LB) is a minimally invasive method for analyzing tumor-derived materials, and this study explores the potential of bile as a superior source of cell-free DNA (cfDNA) compared to plasma for detecting mutations in biliary tract cancers.
- The research involved collecting cfDNA from the bile of 24 cancer cases, including various types of biliary tract cancers, and applying a multigene panel to identify cancer driver mutations.
- Results indicated that bile yielded a higher detection rate of cancer driver mutations, with 54% of bile samples testing positive compared to just 17% of plasma samples, highlighting bile's effectiveness for liquid biopsy analysis.
Situs inversus totalis is a rare congenital malformation in which organs are positioned in a mirror-image relationship to normal conditions. It often presents with vascular and biliary malformations. Only a few reports have pointed out the surgical difficulties in patients with situs inversus totalis, especially in those with perihilar cholangiocarcinoma.
View Article and Find Full Text PDFWe report a case of an elderly patient, 82 years-old, with initially-unresectable pancreatic head cancer, who successfully underwent complete resection of the primary lesion after systemic chemotherapy for 6 months. The patient had a history of pancreatic body-tail resection for intraductal papillary mucinous carcinoma in 2005. In 2020, a routine examination revealed an increased CA19-9 value of 1,958 U/mL and showed a pancreatic head tumor of 35 mm on CT images.
View Article and Find Full Text PDFBackground: Cavernous transformation of the portal vein (CTPV) due to extrahepatic portal vein obstruction is a rare vascular anomaly. Since its symptoms usually appear in childhood, most of the adult cases are detected unexpectedly with other diseases. Only a few reports have described surgical difficulties in patients with CTPV.
View Article and Find Full Text PDF