Prostaglandin E increases the expression of cyclooxygenase-2 in cultured rat microglia.

Prostaglandin E (PGE) plays pivotal roles in controlling microglial activation with the EP receptor, a PGE receptor subtype. Activated microglia are often reported to increase cyclooxygenase (COX)-2 expression, followed by PGE production, but it is unclear whether extracellular PGE is involved in microglial PGE synthesis. In the present study, we report that PGE increases COX-2 protein in microglia.