Publications by authors named "Naohide Oue"

Abnormalities in mucosal immunity are involved in the onset and progression of ulcerative colitis (UC), resulting in a high incidence of colorectal cancer (CRC). While high-mobility group box-1 (HMGB1) is overexpressed during colorectal carcinogenesis, its role in UC-related carcinogenesis remains unclear. In the present study, we investigated the role of HMGB1 in UC-related carcinogenesis and sporadic CRC.

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Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of malignancy, with poor prognosis and rising incidence. IQ motif containing GTPase-activating protein 3 (IQGAP3) is a member of the IQGAPs family of scaffolding proteins that govern multiple cellular activities like cytoskeletal remodeling and cellular signal transduction. This study aimed to analyze the expression and biological function of IQGAP3 in PDAC.

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  • - The study investigates KIF18B, a gene previously unreported in gastric cancer (GC), particularly in the context of gastric mucin phenotype GC, which is prevalent in Japan and associated with mortality.
  • - Analysis involved RNA sequencing and immunohistochemistry on 96 GC cases, revealing KIF18B expression in 54% of cases and its correlation with poor survival rates, as well as associations with other important molecules.
  • - Functional studies showed that silencing KIF18B in GC cells enhanced growth and altered the expression of key proteins involved in cell behavior, suggesting it could be a significant prognostic marker and contribute to understanding the cancer's development.
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  • MCM4, previously linked to gastric cancer, shows strong nuclear expression in upper tract urothelial carcinoma (UTUC), with 62% of cases exhibiting this overexpression and correlating with aggressive tumor characteristics.
  • High MCM4 levels in UTUC are positively associated with poor prognosis, high tumor grade, and invasive characteristics, as well as with other cancer markers like Ki-67 and p53.
  • MCM4 immunocytochemistry enhances urine cytology diagnostics for UC, suggesting its potential as a predictive biomarker for tumor progression and survival outcomes.
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  • Non-Helicobacter pylori Helicobacter (NHPH) may be linked to gastric diseases, but its relationship with gastric cancer is unclear.
  • This study analyzed tissue samples from 73 gastric cancer patients to assess the frequency and impact of NHPH infections compared to previous gastritis-related disease findings.
  • Results indicated no significant differences in NHPH infection rates based on Helicobacter pylori infection status or in relation to the severity of gastritis or gastric cancer characteristics, suggesting that NHPH may not play a crucial role in gastric cancer development in this group.
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Purpose: Upper tract urothelial carcinoma (UTUC) can be divided into renal pelvis tumor (RPT) and ureteral tumor (UT) based on the tumor origin. This study aimed to evaluate the efficacy of neoadjuvant chemotherapy with gemcitabine and cisplatin (NAC-GC) in terms of the pathological outcomes and oncological prognoses in patients with UTUC. We also compared its efficacy between RPT and UT.

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βIII-Tubulin, encoded by the TUBB3 gene, is a microtubule protein. We previously reported that TUBB3 is overexpressed in renal cell carcinoma. We investigated the clinicopathological significance of TUBB3 in upper tract urothelial carcinoma (UTUC) by immunohistochemistry.

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Background: Urothelial carcinoma (UC) is a common type of human cancer and, although urine cytology is a useful method for identifying high-grade UC (HGUC), its ability to diagnose low-grade UC (LGUC) is limited. The authors previously reported that annexin A10 (ANXA10) expression was strongly linked to both papillary and early stage LGUC and was inversely correlated with p53 expression in upper tract UC (UTUC) and bladder UC. However, it remains largely unknown whether ANXA10 is useful as a diagnostic marker for urine cytology.

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A novel large neutral amino acid transporter 1 (LAT1)-specific inhibitor, JPH203, is expected to cause cancer-specific starvation and possess anti-tumor effects; however, its anti-tumor mechanism for colorectal cancer (CRC) remains unclear. We analyzed LAT family gene expressions in public databases using UCSC Xena and evaluated LAT1 protein expression using immunohistochemistry in 154 cases of surgically resected CRC. We also evaluated mRNA expression using polymerase chain reaction in 10 CRC cell lines.

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Although radiotherapy is the standard treatment for (Hp)-negative gastric mucosa-associated lymphoid tissue (MALT) lymphoma, eradication therapy using antibiotics and an acid secretion suppressor can sometimes induce complete remission. We explored predictive markers for the response to eradication therapy for gastric MALT lymphoma that were negative for both and Hp infection using comprehensive RNA sequence analysis. Among 164 gastric MALT lymphoma patients who underwent eradication therapy as primary treatment, 36 were negative for both the fusion gene and Hp infection.

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Bilateral synchronous paratesticular leiomyoma (BSPL) is a rare tumor that originates from smooth muscle cells in the paratesticular region. Four BSPL cases have been reported sporadically, starting with the 1991 report by Aus and Boiesen. Herein, we report the case of a 60-year-old male with a bilateral scrotal mass with a maximum size of 7.

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Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer and the third leading cause of cancer-related deaths. Therefore, there is an urgent need for a novel molecular target for the treatment of PDAC. Kinesin family member C1 (KIFC1) belongs to the kinesin superfamily proteins and has been reported to be involved in the pathogenesis of a wide variety of carcinomas.

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Background/aim: SEC11A gene encodes the SPC18 protein, which has been implicated in tumour progression by inducing the secretion of various growth factors. We investigated the clinical significance of SEC11A expression in gastric cancer (GC) tissues in patients with locally advanced gastric cancer (LAGC) after curative resection.

Patients And Methods: We estimated SEC11A expression in cancer tissues from 253 pStage II/III GC patients who underwent curative resection using quantitative polymerase chain reaction (PCR) and investigated the relationship of SEC11A expression with clinicopathological factors and survival.

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Article Synopsis
  • * The study involved 223 UTUC patients, revealing that those with HV had a higher likelihood of advanced disease characteristics and significantly worse survival rates across several metrics, including progression-free survival (PFS) and overall survival (OS).
  • * HV and lymphovascular invasion (LVI) were identified as independent risk factors, leading to a classification of patients into low, intermediate, and high-risk groups based on these factors, which displayed significant differences in survival outcomes over time.
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  • Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, and one rare subtype is chromophobe RCC (ChRCC) with sarcomatoid differentiation, which lacks clear treatment protocols.
  • This study presents two cases of ChRCC with sarcomatoid differentiation, where one patient was treated with nivolumab after sunitinib failure, and the other received ipilimumab-nivolumab as a first-line treatment.
  • Both therapeutic approaches were effective, but the patients faced immune-related side effects like interstitial nephritis and colitis, suggesting that immune checkpoint therapy can be beneficial for these specific cases.
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Mucin 1 (MUC1) overexpression has been reported in many malignancies and is associated with a poor prognosis. However, the clinicopathological significance of MUC1 in upper tract urothelial carcinoma (UTUC) has not been investigated. We analyzed the expression and distribution of MUC1 in UTUC by immunohistochemistry.

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Background: We sought to identify an optimal combination of survival risk stratification markers in patients with pathological (p) stage II/III gastric cancer (GC) after curative resection.

Methods: We measured the expression levels of 127 genes in pStage II/III GC tissues of two patient cohorts by quantitative polymerase chain reaction (qPCR) and the expression of 1756 proteins between two prognosis (good and poor) groups by proteomic analysis to identify candidate survival stratification markers. Further, immunohistochemistry (IHC) using tumor microarrays (TMAs) in another cohort of patients was performed to identify an optimal biomarker combination for survival stratification in GC patients.

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The global coronavirus disease 2019 (COVID-19) pandemic has led to the rapid development of vaccines against this disease. Despite the success of the international vaccination program, adverse events following vaccination, and the mechanisms behind them, remain poorly understood. Here we present four cases of death following receipt of a second dose of COVID-19 vaccine, with no obvious cause identified at autopsy.

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Myoepithelial neoplasms (MNs) of the lung are extremely rare tumors. Approximately 40 cases of pulmonary MNs have been reported to date. Herein, we report extremely rare cases of different types of pulmonary MN, including cytological features.

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Introduction: Gastric cancer (GC) is a leading cause of cancer-related death worldwide. This study focused on minichromosome maintenance 4 (MCM4), a DNA helicase component that functions in DNA replication. Using spheroid colony formation, having a colony rich in cancer stem cells, this study aimed to investigate the clinicopathological importance of MCM4.

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Introduction: Urothelial carcinoma (UC) is a common type of malignant disease, but little is known about the diagnostic and prognostic markers of upper urinary tract urothelial cancer (UTUC) because of its rarity. To clarify the significance of ANXA10 in UTUC, we studied ANXA10 expression with immunohistochemistry (IHC).

Methods: The expression of ANXA10 was analyzed in the upper and lower urinary tract of UC by IHC in combination with The Cancer Genome Atlas (TCGA) data analysis.

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Introduction: Tryptophan metabolism has been shown to be involved in tumor development. Two main tryptophan-degrading enzymes, tryptophan 2,3-dioxygenase (TDO2) and indoleamine 2,3-dioxygenase 1 (IDO1), may potently promote cancer cell survival and distant metastasis in diverse types of cancer, such as lung and breast cancer. IDO1 overexpression is an independent prognosticator in gastric cancer (GC).

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Background: Genes encoding transmembrane proteins expressed specifically in cancer cells may be ideal therapeutic targets or biomarkers for diagnosis.

Methods: In the present study, we investigated the expression and function of PCDHB9, which encodes transmembrane protein protocadherin B9 in colorectal cancer (CRC).

Results: Immunohistochemical analysis showed that 39 (26%) of 148 CRC cases were positive for protocadherin B9.

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