Publications by authors named "Naoaki Maeda"

Background: Gastro-tracheal fistula is a rare but serious complication after esophageal surgery, often requiring long-term treatment and invasive procedures. Gastro-tracheal fistula usually occurs through the posterior mediastinal route and rarely through the retrosternal route. No previous reports have described gastro-tracheal fistula after retrosternal route reconstruction was cured by conservative treatment.

View Article and Find Full Text PDF
Article Synopsis
  • Tongue pressure (TP) significantly drops in esophageal cancer patients after esophagectomy, but gum-chewing training (GCT) has been shown to boost TP in healthy individuals.
  • This study tested whether perioperative GCT could lower the rate of TP decline and mitigate complications in thoracic esophageal cancer patients post-surgery.
  • Results showed that only 44% of patients in the gum-chewing group experienced reduced TP after surgery, compared to 76% in the historical control group, and the gum-chewing group also had fewer fever days post-operation.
View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on improving the recognition of the recurrent laryngeal nerve (RLN) during robot-assisted minimally invasive esophagectomy (RAMIE) using an artificial intelligence (AI) model, as RLN palsy is a common surgical complication.
  • Researchers developed the AI model using 120 surgical videos and tested its performance against eight additional videos, measuring accuracy with the Intersection over Union (IoU) metric.
  • The results showed that surgeons using the AI significantly outperformed those without it in both the early identification and recognition of the RLN, demonstrating a substantial increase in accuracy and efficiency during the procedure.
View Article and Find Full Text PDF

Background: Pancreatoduodenectomy and subtotal esophagectomy are widely considered the most invasive and difficult surgical procedures in gastrointestinal surgery. Subtotal esophagectomy after pancreatoduodenectomy is expected to be extremely difficult due to complicated anatomical changes, and selecting an appropriate intestinal reconstruction method will also be a difficult task. Therefore, perhaps because the method is considered impossible, there have been few reports of subtotal esophagectomy after pancreatoduodenectomy.

View Article and Find Full Text PDF

Introduction And Importance: A parahiatal hernia (PH) is a rare diaphragmatic hernia (DH) adjacent to but separated from the esophageal hiatus. The surgical repair for PH needs primary suture closure or complicated hernioplasty and the addition of an anti-reflux procedure. This report describes a case of PH with a symptomatic esophageal hiatal hernia managed using three-dimensional (3D) laparoscopy.

View Article and Find Full Text PDF
Article Synopsis
  • The PD-1/PD-L1 pathway significantly contributes to tumor immunosuppression, while cancer-associated fibroblasts (CAFs) also promote tumor growth.
  • An analysis of 140 esophageal cancer cases revealed a correlation between PD-L1 expression and CAF markers, indicating that higher PD-L1 levels in CAFs are linked to poorer patient survival.
  • Experimental studies showed that targeting PD-L1 can lead to increased cancer cell death and enhance immune responses, suggesting that PD-L1-expressing CAFs are potential therapeutic targets to improve cancer treatment outcomes.
View Article and Find Full Text PDF

Background: In Japan, about 6% of esophageal cancers are adenocarcinomas, although most of them arise from Barrett's epithelium. Adenocarcinoma arising from heterotopic gastric mucosa (HGM) is very rare. Due to its rarity, there is no unified view on its treatment strategy and prognosis.

View Article and Find Full Text PDF

Background: This study aimed to determine whether nutritional education, from the preoperative to postoperative period, and nutritional management designed to improve nutritional status alone, could improve patients' health-related self-management and nutritional management skills during the postoperative period.

Methods: We evaluated 101 hospitalised patients with oesophageal cancer who underwent surgery between 2015 and 2016 and received perioperative nutritional education (PERIO-N). The control group included 52 patients who underwent surgery between 2014 and 2015 and were supported only by normal interventions according to the Enhanced Recovery After Surgery protocol.

View Article and Find Full Text PDF

Background: The prognosis of esophageal cancer (EC) with organ invasion is extremely poor. In these cases, definitive chemoradiotherapy (CRT) followed by salvage surgery can be planned; however, the issue of high morbidity and mortality rates persists. Herein, we report the long-term survival of a patient with EC and T4 invasion who underwent a modified two-stage operation after definitive CRT.

View Article and Find Full Text PDF

This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759).

View Article and Find Full Text PDF

Background: Surgical resection of esophageal cancer is frequently performed to achieve a complete cure. However, the postoperative recurrence rate is 36.8-42.

View Article and Find Full Text PDF
Article Synopsis
  • - Cancer-associated fibroblasts (CAFs) contribute significantly to tumor growth and immunosuppression, largely influenced by interleukin-6 (IL-6), which is linked to a more aggressive tumor environment.
  • - Anti-IL-6 receptor antibodies were investigated as a potential systemic therapy to counteract the effects of IL-6 and CAFs, demonstrating the ability to inhibit tumor progression in mouse models by regulating the activation of HIF1α, a key factor in cell growth and survival.
  • - Clinical findings revealed a strong correlation between IL-6 expression and worse patient outcomes, indicating that targeting IL-6 could potentially enhance cancer treatment by alleviating immune suppression and improving survival rates.
View Article and Find Full Text PDF
Article Synopsis
  • Salvage surgery for esophageal cancer after definitive chemoradiotherapy is effective but has a high risk of complications.
  • A case study highlights a 73-year-old man with residual esophageal cancer and a mediastinal fistula who successfully underwent robot-assisted minimally invasive esophagectomy (RAMIE).
  • The advantages of RAMIE, including effective monopolar dissection for dealing with difficult scar tissue, contributed to a safe surgical outcome without complications.
View Article and Find Full Text PDF

Background: Body weight loss (BWL) and skeletal muscle loss (SML) are inevitable after gastrectomy for gastric cancer (GC) and can decrease patients' quality of life (QOL) and survival.

Objective: The aim of this retrospective study was to evaluate the effect of perioperative and post-discharge patient participation in continuous nutritional counseling (CNC) on post-gastrectomy BWL and SML.

Methods: Ninety-three patients with GC who underwent curative gastrectomy between March 2018 and July 2019 were analyzed.

View Article and Find Full Text PDF

Background: The standard treatment for locally advanced esophageal cancer is preoperative chemotherapy with cisplatin and 5-fluorouracil (CF), followed by surgery. Although docetaxel plus cisplatin and 5-fluorouracil (DCF) has been reported to have favorable outcomes, no study has compared its therapeutic efficacy to that of standard treatment. This study aimed to compare the therapeutic effects of CF and DCF in the real world by matching patient background factors using propensity scores.

View Article and Find Full Text PDF

Background/aim: Postoperative body weight loss (BWL) and skeletal muscle loss (SML) after gastrectomy are associated with a decline in quality of life and worse longterm prognosis in gastric cancer (GC) patients. This study aimed to evaluate the efficacy of amino acids nutrition on BWL and SML in the early period following gastrectomy.

Patients And Methods: The parameters of body composition were measured by bioelectrical impedance analysis in the patients undergoing radical gastrectomy for GC and analyzed retrospectively.

View Article and Find Full Text PDF

Background: Verrucous carcinoma of the esophagus (VCE) is a rare tumor that is difficult to diagnose. In most cases, biopsies show nonspecific inflammatory and hyperkeratotic changes and do not show malignant findings. Most VCEs are slowly growing, locally advanced tumors with few metastases.

View Article and Find Full Text PDF

Purpose: To investigate if early exercise can help prevent skeletal muscle loss and improve the clinical outcomes of esophageal cancer patients receiving preoperative neoadjuvant chemotherapy (NAC).

Methods: This was a single-center, retrospective observational cohort study of 110 patients with advanced esophageal cancer. We analyzed the effect of early exercise on the risk of skeletal muscle loss (defined as > 2.

View Article and Find Full Text PDF

Approximately 4% of patients with esophageal cancer develop a second primary malignancy in the upper gastrointestinal trunk. However, hepatectomy following esophagectomy for esophageal cancer has rarely been reported. We report the case of a 70-year-old man who underwent an esophagectomy for esophageal cancer with retrosternal gastric tube reconstruction.

View Article and Find Full Text PDF

Background: Multidisciplinary team (MDT) approach has become a standard for perioperative patient care, including in esophageal cancer. In our institution, the Perioperative Management Center (PERiO) has been doing an MDT approach for patients undergoing esophageal cancer surgery since 2009. On the other hand, neoadjuvant therapy has also been becoming standard for many malignancies, including esophageal cancer.

View Article and Find Full Text PDF

Background: Although the main manifestation of giant paraesophageal hernia (PEH) is disordered meal passage due to gastric torsion, the contents of the hernia sometimes squeeze the heart and lungs and induce the symptoms of respiratory or heart failure. Furthermore, the quality of life (QOL) of patients with a heavy cardiac load deteriorates. In this study, changes in a heart failure marker and symptoms of cases with a giant PEH from before to after laparoscopic surgery were examined.

View Article and Find Full Text PDF

Background: We have recently standardized upper mediastinal lymph node dissection (UMLND) using a microanatomy-based concept in thoracoscopic esophagectomy in the prone position (TEPP), and introduced robot-assisted minimally invasive esophagectomy (RAMIE) using the same concept as in TEPP while aiming at solo surgery. The purpose of this study was to investigate the outcomes of RAMIE using the microanatomy-based concept in the initial introduction phase.

Methods: We have performed more than 500 TEPP procedures as minimally invasive esophagectomy (MIE).

View Article and Find Full Text PDF

Background: Incidence of esophagogastric junction (EGJ) carcinoma has been increasing worldwide. Several studies revealed that the distance from the EGJ to the proximal edge of the primary tumor (esophageal invasion: EI) may be a significant indicator of metastasis in the mediastinal lymph nodes in patients with Siewert type II carcinomas. However, few studies have been conducted in patients with carcinomas located at Siewert type II sequentially to upper carcinomas (Siewert type I) for mediastinal metastasis regardless of histological types.

View Article and Find Full Text PDF

An aberrant right subclavian artery (ARSA) is one of the famous anatomical abnormalities with a prevalence of 0.16-4.4%.

View Article and Find Full Text PDF
Article Synopsis
  • Tracheobronchial diverticula (DVs) can pose risks during esophagectomy, particularly requiring careful dissection around the trachea and bronchi.
  • A study of 180 esophageal cancer patients revealed a 5.0% incidence of tracheal DVs and 40.0% for bronchial DVs, with specific locations and sizes recorded.
  • Two cases of bronchial DV injuries during thoracoscopic esophagectomy were successfully repaired, highlighting the importance of thorough pre-surgery evaluations and careful repairs to prevent complications.
View Article and Find Full Text PDF