Publications by authors named "Nao Tahara"
Article Synopsis
- Corticobasal degeneration (CBD) is a complex neurodegenerative disorder that requires pathological confirmation for an accurate diagnosis, and this study focused on Japanese patients to examine their clinical traits.
- Out of 34 initially reviewed patients, 31 were analyzed, with a mean age of onset at 63.3 years and a median disease duration of 6 years; the most common clinical phenotype was progressive supranuclear palsy syndrome (PSPS), affecting 64.5% of participants.
- The study highlighted that a significant number of patients (90.3%) experienced dysphagia early in the disease course, which is linked to reduced survival, while those receiving tube feeding had better survival rates compared to those who did not
Aims: Corticobasal degeneration (CBD) is a rare neurodegenerative disorder. The status of the inferior olivary nucleus (ION) in CBD has been inadequately investigated. In this study, we conducted a pathological investigation of the ION in CBD.
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- The m. 3243A>G mutation is linked to mitochondrial diseases like MELAS, which lead to symptoms such as muscle weakness, brain dysfunction, and stroke-like episodes.
- A study of six autopsied cases with the mutation revealed significant brain damage, especially in certain lobes, while the medial temporal lobe remained unaffected despite high mtDNA heteroplasmy.
- Common neurological findings were inconsistent in mutant cases, suggesting distinct neuropathological markers, including unique changes in brain vessel structure and choroidal epithelial cells, which could aid in diagnosing mitochondrial disorders.
A 70-year-old woman visited our hospital with hypertension, diplopia, and right orbital pain. Neurological examination revealed right ophthalmoplegia. CT angiography and MRI identified a right persistent trigeminal artery (PTA), right persistent hypoglossal artery, and bovine aortic arch.
View Article and Find Full Text PDFObjective: We investigated recurrent stroke volume with nonvalvular atrial fibrillation (NVAF) patients treated with non-vitamin K antagonist oral anticoagulants (NOACs) about clinical backgrounds and number of recurrent stroke.
Methods: We administered 4 NOACs, dabigatran, rivaroxaban, apixaban, and edoxaban in 101 postcardioembolic strokes with NVAF. In a retrospective study, we measured recurrent stroke volume with magnetic resonance imaging volumetric software and compared them between 10 vitamin K anticoagulant (VKA: warfarin) cases and 13 NOAC cases under anticoagulant therapy.