[The Effectiveness of Epidural Droperidol for Prophylaxis of Postoperative Nausea and Vomiting: A Comparative Study of Droperidol and Adrenaline].

Background: Intravenous droperidol has strong evidence for antiemetic efficacy in high risk patients for prevention of postoperative nausea and vomiting (PONV). However it is not clear whether continuous epidural administration of doroperidol prevent PONV. It has been reported that epidural adrenaline decreases PONV; therefore we prospectively compared the effectiveness of epidural droperidol and adrenaline for prophylaxis of PONV.

Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity.

Rationale And Objectives: Although many clinical physiology and epidemiology studies show an association between obstructive sleep apnea (OSA) and markers of insulin resistance, no causal pathway has been established. The purpose of the current study was to determine if the intermittent hypoxia (IH) stimulus that characterizes OSA causes insulin resistance in the absence of obesity. Furthermore, we assessed the impact of IH on specific metabolic function in liver and muscle.

Genetic background affects cardiovascular responses to obstructive and simulated apnea.

We have recently demonstrated that genetic background significantly impacts the blood pressure and heart rate response to hypoxia (Campen MJ, Tagaito Y, Li J, Balbir A, Tankersley CG, Smith P, Schwartz A, and O'Donnell CP. Physiol Genomics 20: 15-20, 2005). Because hypoxia is considered a mediator of the acute and chronic cardiovascular complications of obstructive sleep apnea, we investigated whether genetic factors also influence the cardiovascular response to experimentally induced obstructive apnea (OA) and simulated apnea (SA).

Respiratory and behavioural compensation during chronic severe loading in a hypoxic rat model.

1. Respiratory load compensation plays an important role in the maintenance of an appropriate level of ventilation. We investigated the ventilatory and behavioural responses to a severe load causing both hypercapnia and hypoxaemia in a rat model.

Ventilatory load compensation response to long-term chest compression in rat model.

Short-term chest compression has been shown to decrease tidal volume and increase respiratory frequency. The present study was designed to assess and characterize the effect of long-term chest compression on breathing pattern and blood gases in awake rats. Chest compression was carried out by inflating a pneumatic cuff placed around the chest to a pressure of 25 mmHg and the pressure was maintained for 28 days.